doi: 10.1073/pnas.72.1.279.
A mechanism to activate branch migration between homologous DNA molecules in genetic recombination
- PMID: 1054504
- PMCID: PMC432287
- DOI: 10.1073/pnas.72.1.279
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A mechanism to activate branch migration between homologous DNA molecules in genetic recombination
Proc Natl Acad Sci U S A.
1975 Jan.
Abstract
A mechanism to activate branch migration between homologous DNA molecules is described that leads to synapsis in genetic recombination. The model involves a restriction-like endonucleolytic enzyme that first nicks DNA (to produce single-strand breaks) on strands of opposite polarity at symmetrically arranged nucleotide sequences (located at ends of genes or operons). This is followed by local denaturation of the region, promoted by a single-strand-specific DNA binding protein (i.e., an unwinding protein). Hydrogen-bounding between homologous DNA molecules can then be initiated and this allows for subsequent propagation of hybrid DNA in the pathway to formation of the synapton structure.
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