Comment
doi: 10.1126/science.286.5441.950.
A species of small antisense RNA in posttranscriptional gene silencing in plants
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- PMID: 10542148
- DOI: 10.1126/science.286.5441.950
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Comment
A species of small antisense RNA in posttranscriptional gene silencing in plants
Science.
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Abstract
Posttranscriptional gene silencing (PTGS) is a nucleotide sequence-specific defense mechanism that can target both cellular and viral mRNAs. Here, three types of transgene-induced PTGS and one example of virus-induced PTGS were analyzed in plants. In each case, antisense RNA complementary to the targeted mRNA was detected. These RNA molecules were of a uniform length, estimated at 25 nucleotides, and their accumulation required either transgene sense transcription or RNA virus replication. Thus, the 25-nucleotide antisense RNA is likely synthesized from an RNA template and may represent the specificity determinant of PTGS.
Comment on
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Molecular biology. Candidate 'gene silencers' found.Science. 1999 Oct 29;286(5441):886. doi: 10.1126/science.286.5441.886a. Science. 1999. PMID: 10577233 No abstract available.
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