doi: 10.1016/s0960-894x(99)00468-0.
Combinatorial search of substituted beta-cyclodextrins for phosphatase-like activity
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- PMID: 10509920
- DOI: 10.1016/s0960-894x(99)00468-0
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Combinatorial search of substituted beta-cyclodextrins for phosphatase-like activity
Bioorg Med Chem Lett.
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Abstract
Thirteen per-6-akylamino-6-deoxy-beta-cyclodextrin libraries (beta-CD libraries) were generated by a solution-phase combinatorial synthesis starting from per-6-iodo-6-deoxy-beta-CD and different combinations of eleven individual amine nucleophiles. Certain libraries showed the ability to hydrolyzep-nitrophenyl phosphate in the presence of Zn2+.
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