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Review
. 1999 Sep;155(3):683-94.
doi: 10.1016/S0002-9440(10)65166-8.

DNA copy number losses in human neoplasms

S Knuutila  1 , Y Aalto, K Autio, A M Björkqvist, W El-Rifai, S Hemmer, T Huhta, E Kettunen, S Kiuru-Kuhlefelt, M L Larramendy, T Lushnikova, O Monni, H Pere, J Tapper, M Tarkkanen, A Varis, V M Wasenius, M Wolf, Y Zhu
Affiliations
Review

DNA copy number losses in human neoplasms

S Knuutila et al. Am J Pathol. 1999 Sep.

Abstract

This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www. helsinki.fi/ approximately lglvwww/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22-q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22-q23 (25%), 10q23 (25%), 10q25-qter (25%),15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.

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Figures

Figure 1.
Figure 1.
Summary of losses in 73 tumor entities reported in Table 2. Each line by a chromosome arm represents a tumor entity. Red and black lines indicate that the loss was found in at least 30% of the cases in that particular tumor type (numbers refer to numbering in Table 2 online). A red line signifies that two different publications reported the loss, and a black line shows that the loss was published in one report only. A blue line indicates that the loss was involved in 10 to 29% of the cases. A bold line shows the smallest common overlapping area of the losses.
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