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Review
. 1999;8(10):1939-45.
doi: 10.1093/hmg/8.10.1939.

Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences

M Carrington  1 , M Dean, M P Martin, S J O'Brien
Affiliations
Review

Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences

M Carrington et al. Hum Mol Genet. 1999.

Abstract

The chemokine receptor gene, CCR5, has become a central theme in studies of host genetic effects on HIV-1 pathogenesis ever since the discovery that the CCR5 molecule serves as a major cell surface co-receptor for the virus. A growing number of genetic variants within the coding and 5' regulatory region of CCR5 have been identified, several of which have functional consequences for HIV-1 pathogenesis. Here we review the CCR5 literature describing CCR5 polymorphism and the functional ramifications that several of these variants have on HIV-1 infection and progression to AIDS. The multiplicity of CCR5 genetic effects on HIV-1 disease underscores the critical importance of this gene in controlling AIDS pathogenesis and provides the logic for develop-ment of therapeutic strategies that target the interaction of HIV-1 envelope and CCR5 in HIV-1 associated disease.

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