Evaluation of lacidipine (a calcium blocker) in the treatment of hypertension in black African people: a double-blind comparison with hydrochlorothiazide
- PMID: 10456135
Evaluation of lacidipine (a calcium blocker) in the treatment of hypertension in black African people: a double-blind comparison with hydrochlorothiazide
Abstract
Diuretics and calcium blockers are particularly effective in the treatment of hypertension in Blacks, who, characteristically, have low-renin hypertension. The efficacy and tolerable of lacidipine (a calcium) blocker of the dihydropyridine class) and hydrochlorothiazide (a diuretic) were compared in a 12 week double-blind randomised parallel group study of Nigerians with essential hypertension. Lacidipine was given at a starting dose of 4 mg daily by mouth and increased to 6 mg if there was no satisfactory response at 4 weeks, and hydrochlorothiazide was stared at 25 mg daily by mouth and increased to 50 mg if necessary. Twenty-four patients (8 male) in the lacidipine group and 17 (5 male) in the hydrochlorothiazide group were evaluable at the end of the trial. In the lacidipine group, SBP was significantly reduced from 157 +/- 14 mmHg to 146 +/- 24 mmHg (P < 0.00001) and DBP from 90 +/- 9 mmHG to 87 +/- 15 mmHg (P < 0.00001) with BP normalisation rates of 67% and 79% at 4 weeks and 12 weeks, respectively. In the hydrochlorothiazide group, SBP was significantly reduced from 16.4 +/- 19 mmHg to 141 +/- 17 mmHg (P < 0.00001) and DBP from 102 +/- 6 mmHG to 89 +/- 7 mmHg (P < 0.00001) with normalisation rates of 77% and 82% at 4 weeks and 12 weeks respectively. The groups did not differ in BP reduction nor normalisation rates. There were no reported side effects.
Similar articles
-
Lacidipine, hydrochlorothiazide and their combination in systolic hypertension in the elderly.J Hypertens. 1997 Dec;15(12 Pt 1):1503-10. doi: 10.1097/00004872-199715120-00019. J Hypertens. 1997. PMID: 9431858 Clinical Trial.
-
The effect of lacidipine on patients with mild to moderate hypertension and the effect of a combination of lacidipine and hydrochlorothiazide in the treatment of hypertension uncontrolled after four weeks of lacidipine treatment: an open study.West Afr J Med. 1998 Jan-Mar;17(1):42-6. West Afr J Med. 1998. PMID: 9643160 Clinical Trial.
-
A double-blind comparison of the efficacy and safety of lacidipine and hydrochlorothiazide in essential hypertension. The Southern Italy Lacidipine Study Group.J Cardiovasc Pharmacol. 1991;17 Suppl 4:S35-7. J Cardiovasc Pharmacol. 1991. PMID: 1726004 Clinical Trial.
-
Lacidipine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of hypertension.Drugs. 1994 Aug;48(2):274-96. doi: 10.2165/00003495-199448020-00010. Drugs. 1994. PMID: 7527328 Review.
-
Safety aspects of treatment with lacidipine--a slow-onset, long-acting calcium antagonist.Blood Press. 1996 Jul;5(4):241-9. doi: 10.3109/08037059609079678. Blood Press. 1996. PMID: 8809376 Review.
Cited by
-
Pharmacotherapy for hypertension in Sub-Saharan Africa: a systematic review and network meta-analysis.BMC Med. 2020 Mar 27;18(1):75. doi: 10.1186/s12916-020-01530-z. BMC Med. 2020. PMID: 32216794 Free PMC article.
-
Lacidipine: a review of its use in the management of hypertension.Drugs. 2003;63(21):2327-56. doi: 10.2165/00003495-200363210-00008. Drugs. 2003. PMID: 14524737 Review.
-
Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea.Korean Circ J. 2010 Dec;40(12):632-8. doi: 10.4070/kcj.2010.40.12.632. Epub 2010 Dec 31. Korean Circ J. 2010. PMID: 21267385 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical