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Review
. 1999 Aug;11(4):293-303.
doi: 10.1006/smim.1999.0185.

Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s)

P Poussier  1 , M Julius
Affiliations
Review

Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s)

P Poussier et al. Semin Immunol. 1999 Aug.

Abstract

The thymus-independent T lymphopoietic capacity of the murine intestinal mucosa has been established. Cryptopatches have now been identified as the location of the elusive precursors for gut-derived T cells. These cryptopatch cells have been shown to give rise to intestinal T cells expressing either TCRgammadelta or TCRalphabeta. Here we discuss the role of MHC in the development and selection of gut-derived T cells. Through the analysis of iIEL selection in animals expressing a transgenic TCRalphabeta, in the presence or absence of p56(lck), we discuss lineage relationships among CD4(-)8(+) iIEL subsets, and their possible function(s).

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