Review
doi: 10.2337/diabetes.48.7.1353.
Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?
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- PMID: 10389838
- DOI: 10.2337/diabetes.48.7.1353
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Review
Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?
Diabetes.
1999 Jul.
Abstract
Genome-scale analysis in type 1 diabetes has resulted in a number of non-major histocompatibility complex loci of varying levels of statistical significance. In no case has a specific gene been proven to be the source of genetic linkage at any candidate locus. Comparative analysis of the position of loci for type 1 diabetes with candidate loci from other autoimmune/inflammatory diseases shows considerable overlap. This supports a hypothesis that the underlying genetic susceptibility to type 1 diabetes may be shared with other clinically distinct autoimmune diseases such as systemic lupus erythemastosus, multiple sclerosis, and Crohn's Disease.
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