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. 1999 Jun 11;452(3):301-4.
doi: 10.1016/s0014-5793(99)00678-x.

Thiazolidinedione inhibits production of RANTES in a cytokine-treated human lung epithelial cell line

A Momoi  1 , K Murao, H Imachi, Y Sayo, H Nakamura, H Hosokawa, M Sato, J Fujita, H Okada, T Ishida, J Takahara
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Free article

Thiazolidinedione inhibits production of RANTES in a cytokine-treated human lung epithelial cell line

A Momoi et al. FEBS Lett. .
Free article

Abstract

The chemokine RANTES is a potent chemoattractant for eosinophils. RANTES is produced by lung epithelial cells during eosinophil-rich inflammatory diseases such as asthma. In this study, we examined the effects of thiazolidinediones (TZD) on RANTES expression in a human lung epithelial cell line, A549. In A549 cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous RANTES protein secretion, mRNA expression, and promoter activity. The TZD inhibited these effects. Our data indicate that the suppression of the expression of RANTES can be accomplished by TZD treatment, raising the possibility that TZD might be of therapeutic value in diseases such as asthma.

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