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. 1999 Jun 5;258(2):389-95.
doi: 10.1006/viro.1999.9734.

Neuronal expression of NOS-1 is required for host recovery from viral encephalitis

T Komatsu  1 , D D Ireland, N Chen, C S Reiss
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Free article

Neuronal expression of NOS-1 is required for host recovery from viral encephalitis

T Komatsu et al. Virology. .
Free article

Abstract

The role of nitric oxide synthase (NOS) in host defense and clearance of vesicular stomatitis virus (VSV) from the central nervous system (CNS) was examined. NOS-1, NOS-2, and NOS-3 knockout mice were infected with VSV and were treated with either IL-12 or medium. IL-12 treatment resulted in substantially decreased VSV titers in wildtype and NOS-3 knockout mice, but had a marginal effect in the NOS-1 and NOS-2 knockout mice. NOS-1 expression in neurons was associated with survival from VSV infection. The data indicate that the enzyme activity is local, since NOS-2 expression in microglia and inflammatory macrophages and NOS-3 expression in astrocytes, endothelial cells, and ependymal cells did not compensate.

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