Review
doi: 10.1016/S0959-440X(99)80045-1.
Exposing the kinetic traps in RNA folding
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- PMID: 10361090
- DOI: 10.1016/S0959-440X(99)80045-1
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Review
Exposing the kinetic traps in RNA folding
Curr Opin Struct Biol.
1999 Jun.
Abstract
Large ribozymes fold on a 'glacial' timescale compared to the folding of their protein counterparts. The sluggish folding exhibited by large RNAs results from the formation of kinetically trapped, misfolded intermediates, which are nonessential features of the folding mechanism. Newly developed mutant ribozymes that avoid kinetic traps should facilitate the study of the RNA folding problem.
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