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. 1999 May 7;274(19):12955-8.
doi: 10.1074/jbc.274.19.12955.

Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB

J Bertin  1 , W J Nir, C M Fischer, O V Tayber, P R Errada, J R Grant, J J Keilty, M L Gosselin, K E Robison, G H Wong, M A Glucksmann, P S DiStefano
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Free article

Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB

J Bertin et al. J Biol Chem. .
Free article

Abstract

The nematode CED-4 protein and its human homolog Apaf-1 play a central role in apoptosis by functioning as direct activators of death-inducing caspases. A novel human CED-4/Apaf-1 family member called CARD4 was identified that has a domain structure strikingly similar to the cytoplasmic, receptor-like proteins that mediate disease resistance in plants. CARD4 interacted with the serine-threonine kinase RICK and potently induced NF-kappaB activity through TRAF-6 and NIK signaling molecules. In addition, coexpression of CARD4 augmented caspase-9-induced apoptosis. Thus, CARD4 coordinates downstream NF-kappaB and apoptotic signaling pathways and may be a component of the host innate immune response.

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