doi: 10.1126/science.284.5415.819.
Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells
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- PMID: 10221917
- DOI: 10.1126/science.284.5415.819
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Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells
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Abstract
Langerhans' cells migrating from contact-sensitized skin were found to up-regulate expression of macrophage-derived chemokine (MDC) during maturation into lymph node dendritic cells (DCs). Naïve T cells did not migrate toward MDC, but antigen-specific T cells rapidly acquired MDC responsiveness in vivo after a subcutaneous injection of antigen. In chemotaxis assays, maturing DCs attracted activated T cells more strongly than naïve T cells. These studies identified chemokine up-regulation as part of the Langerhans' cell maturation program to immunogenic T cell-zone DC. Preferential recruitment of activated T cells may be a mechanism used by maturing DCs to promote encounters with antigen-specific T cells.
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