Review
doi: 10.1016/s0966-842x(99)01468-7.
Bordatella pertussis adenylate cyclase: a toxin with multiple talents
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- PMID: 10217833
- DOI: 10.1016/s0966-842x(99)01468-7
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Review
Bordatella pertussis adenylate cyclase: a toxin with multiple talents
Trends Microbiol.
1999 Apr.
Abstract
Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin (CyaA) that is able to deliver its amino-terminal catalytic domain into the cytosol of eukaryotic cells. The novelty of the structural organization and conformational flexibility of the CyaA catalytic domain has opened up the way for exploiting this protein as a tool for several biological applications, including epitope delivery, protein targeting and characterization of protein-protein interactions.
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