Review
doi: 10.1046/j.1440-1711.1999.00788.x.
Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis
Affiliations
- PMID: 10101687
- DOI: 10.1046/j.1440-1711.1999.00788.x
Item in Clipboard
Review
Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis
Immunol Cell Biol.
1999 Feb.
Abstract
Cysteine proteases of the caspase family are crucial mediators of apoptosis. All mammalian cells contain a large number of caspases. Although many caspases are activated in a cell committed to apoptosis, recent data from caspase gene knockout mice suggest that individual caspases may be involved in the cell and stimulus-specific pathways of cell death. The gene disruption studies also establish the functional hierarchy between two structurally distinct classes of caspases. The present review discusses these recent findings and elaborates on how these mutant mouse models have helped the understanding of the mechanisms that govern programmed cell death in the immune and other systems.
Similar articles
-
Caspases--their role in apoptosis and other physiological processes as revealed by knock-out studies.Arch Immunol Ther Exp (Warsz). 2002;50(1):19-34. Arch Immunol Ther Exp (Warsz). 2002. PMID: 11916306 Review.
-
Head involution defective (Hid)-triggered apoptosis requires caspase-8 but not FADD (Fas-associated death domain) and is regulated by Erk in mammalian cells.J Biol Chem. 2002 Sep 20;277(38):35097-104. doi: 10.1074/jbc.M206445200. Epub 2002 Jul 16. J Biol Chem. 2002. PMID: 12122017
-
TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent.Am J Physiol Gastrointest Liver Physiol. 2004 Aug;287(2):G436-43. doi: 10.1152/ajpgi.00019.2004. Epub 2004 Apr 8. Am J Physiol Gastrointest Liver Physiol. 2004. PMID: 15075251
-
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.Cell Death Differ. 1998 Apr;5(4):271-88. doi: 10.1038/sj.cdd.4400370. Cell Death Differ. 1998. PMID: 10200473
-
Regulation of apoptosis and cell cycle activity in rheumatoid arthritis.Curr Mol Med. 2001 Nov;1(5):597-608. doi: 10.2174/1566524013363429. Curr Mol Med. 2001. PMID: 11899234 Review.
Cited by
-
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease.J Neurosci. 2001 Dec 15;21(24):9519-28. doi: 10.1523/JNEUROSCI.21-24-09519.2001. J Neurosci. 2001. PMID: 11739563 Free PMC article.
-
Prix Fixe: Efferocytosis as a Four-Course Meal.Curr Top Microbiol Immunol. 2017;403:1-36. doi: 10.1007/82_2015_467. Curr Top Microbiol Immunol. 2017. PMID: 26305046 Free PMC article. Review.
-
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain.Neurochem Res. 2003 Feb;28(2):307-18. doi: 10.1023/a:1022337519035. Neurochem Res. 2003. PMID: 12608703
-
A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.Mol Cell Biol. 2011 Jun;31(11):2287-98. doi: 10.1128/MCB.01381-10. Epub 2011 Mar 28. Mol Cell Biol. 2011. PMID: 21444724 Free PMC article.
-
Pathways of apoptosis and importance in development.J Cell Mol Med. 2005 Apr-Jun;9(2):345-59. doi: 10.1111/j.1582-4934.2005.tb00360.x. J Cell Mol Med. 2005. PMID: 15963254 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
