DNA vaccines for prophylactic or therapeutic immunization against hepatitis B virus
- PMID: 10100411
DNA vaccines for prophylactic or therapeutic immunization against hepatitis B virus
Abstract
DNA vaccines, with which the antigen is synthesized in vivo after direct introduction of its encoding sequences, offer a unique method of immunization that may overcome many of the deficits of traditional antigen-based vaccines. By virtue of the sustained in vivo antigen synthesis and the comprised stimulatory CpG motifs, plasmid DNA vaccines appear to induce strong and long-lasting humoral (anti-bodies) and cell-mediated (T-help, other cytokine functions and cytotoxic T-cells) immune responses. In animal models, DNA vaccines against hepatitis B virus (HBV) give humoral and cell-mediated immunity superior to that of the current traditional antigen-based vaccines, indicating the possibility of a more effective prophylactic vaccine against HBV. Furthermore, DNA vaccines can overcome tolerance to and expression of HBV proteins in a transgenic mouse model of the HBV chronic carrier, opening up the possibility of an effective therapeutic DNA vaccine to treat chronic carriers of HBV.
Similar articles
-
A novel HBV DNA vaccine based on T cell epitopes and its potential therapeutic effect in HBV transgenic mice.Int Immunol. 2005 Oct;17(10):1293-302. doi: 10.1093/intimm/dxh305. Epub 2005 Aug 19. Int Immunol. 2005. PMID: 16113237
-
Engineering enhancement of the immune response to HBV DNA vaccine in mice by the use of LIGHT gene adjuvant.J Virol Methods. 2008 Nov;153(2):142-8. doi: 10.1016/j.jviromet.2008.07.013. Epub 2008 Sep 3. J Virol Methods. 2008. PMID: 18722475
-
A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 gene enhanced potency of HBV DNA vaccine.Vaccine. 2006 Apr 12;24(16):3321-31. doi: 10.1016/j.vaccine.2006.01.012. Epub 2006 Jan 19. Vaccine. 2006. PMID: 16472546
-
Revealing the potential of DNA-based vaccination: lessons learned from the hepatitis B virus surface antigen.Biol Chem. 2001 Apr;382(4):543-52. doi: 10.1515/BC.2001.068. Biol Chem. 2001. PMID: 11405219 Review.
-
DNA-based immunotherapy: potential for treatment of chronic viral hepatitis?Rev Med Virol. 2002 Sep-Oct;12(5):297-319. doi: 10.1002/rmv.359. Rev Med Virol. 2002. PMID: 12211043 Review.
Cited by
-
DNA vaccines encoding viral glycoproteins induce nonspecific immunity and Mx protein synthesis in fish.J Virol. 2000 Aug;74(15):7048-54. doi: 10.1128/jvi.74.15.7048-7054.2000. J Virol. 2000. PMID: 10888644 Free PMC article.
-
Targeting hepatitis B virus antigens to dendritic cells by heat shock protein to improve DNA vaccine potency.World J Gastroenterol. 2007 Nov 28;13(44):5911-7. doi: 10.3748/wjg.v13.i44.5911. World J Gastroenterol. 2007. PMID: 17990356 Free PMC article.
-
Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN.Cancer Immunol Immunother. 2007 Aug;56(8):1251-64. doi: 10.1007/s00262-006-0276-x. Epub 2007 Jan 23. Cancer Immunol Immunother. 2007. PMID: 17242927 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical