Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
- PMID: 10069335
- DOI: 10.1016/s0896-6273(00)81090-9
Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
Abstract
The ability of neuronal growth cones to be guided by extracellular cues requires intimate communication between signal transduction systems and the dynamic actin-based cytoskeleton at the leading edge. Profilin, a small, actin-binding protein, has been proposed to be a regulator of the cell motility machinery at leading edge membranes. However, its requirement in the developing nervous system has been unknown. Profilin associates with members of the Enabled family of proteins, suggesting that Profilin might link Abl function to the cytoskeleton. Here, genetic analysis in Drosophila is used to demonstrate that mutations in Profilin (chickadee) and Abl (abl) display an identical growth cone arrest phenotype for axons of intersegmental nerve b (ISNb). Moreover, the phenotype of a double mutant suggests that these components function together to control axonal outgrowth.
Similar articles
-
The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance.Neuron. 1999 Feb;22(2):301-12. doi: 10.1016/s0896-6273(00)81091-0. Neuron. 1999. PMID: 10069336
-
Calmodulin and profilin coregulate axon outgrowth in Drosophila.J Neurobiol. 2001 Apr;47(1):26-38. doi: 10.1002/neu.1013. J Neurobiol. 2001. PMID: 11257611
-
A role for Abl in Notch signaling.Neuron. 1998 Apr;20(4):667-81. doi: 10.1016/s0896-6273(00)81007-7. Neuron. 1998. PMID: 9581760
-
Drosophila abl and genetic redundancy in signal transduction.Trends Genet. 1991 Nov-Dec;7(11-12):351-5. doi: 10.1016/0168-9525(91)90254-f. Trends Genet. 1991. PMID: 1820686 Review.
-
Profilin: at the crossroads of signal transduction and the actin cytoskeleton.Bioessays. 1994 Jul;16(7):465-72. doi: 10.1002/bies.950160705. Bioessays. 1994. PMID: 7945274 Review.
Cited by
-
Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases.Biochem J. 2002 Aug 15;366(Pt 1):73-7. doi: 10.1042/BJ20020298. Biochem J. 2002. PMID: 12014990 Free PMC article.
-
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.Genes Dev. 1999 Sep 15;13(18):2400-11. doi: 10.1101/gad.13.18.2400. Genes Dev. 1999. PMID: 10500097 Free PMC article.
-
Axon branching requires interactions between dynamic microtubules and actin filaments.J Neurosci. 2001 Dec 15;21(24):9757-69. doi: 10.1523/JNEUROSCI.21-24-09757.2001. J Neurosci. 2001. PMID: 11739584 Free PMC article.
-
Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors.Elife. 2015 May 19;4:e05196. doi: 10.7554/eLife.05196. Elife. 2015. PMID: 25988807 Free PMC article.
-
Drosophila as a genetic and cellular model for studies on axonal growth.Neural Dev. 2007 May 2;2:9. doi: 10.1186/1749-8104-2-9. Neural Dev. 2007. PMID: 17475018 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
