Review
doi: 10.3109/08830189809054411.
Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis
Affiliations
- PMID: 10036640
- DOI: 10.3109/08830189809054411
Item in Clipboard
Review
Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis
Int Rev Immunol.
1998.
Abstract
Two of the key events in the pathogenesis of rheumatoid arthritis are the synovial cell proliferation and lymphocyte infiltration into the synovium. The resulting synovitis is longlasting and leads to destructive arthritis, which is a hallmark of rheumatoid arthritis. Accumulating evidence suggests that one of the key biochemical events in the altered cell function of RA is phosphorylation of the tyrosine residues of proteins. In this paper we review the cellular components participating in the chronic inflammation of RA joints. We present the results of analyzing tyrosine phosphorylated proteins of synovial cells from RA patients and discuss a possible pathogenic role of non-receptor tyrosine kinase in RA.
Similar articles
-
beta1 integrin-mediated signaling induces intercellular adhesion molecule 1 and Fas on rheumatoid synovial cells and Fas-mediated apoptosis.Arthritis Rheum. 2003 May;48(5):1239-48. doi: 10.1002/art.10941. Arthritis Rheum. 2003. PMID: 12746897
-
Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442. Arthritis Rheumatol. 2016. PMID: 26414708 Free PMC article.
-
The role of adhesion molecules in the pathogenesis of rheumatoid arthritis.Autoimmunity. 1993;16(1):69-76. doi: 10.3109/08916939309010649. Autoimmunity. 1993. PMID: 8136468 Review.
-
Integrin signalling and tyrosine phosphorylation: just the FAKs?Trends Cell Biol. 1998 Apr;8(4):151-7. doi: 10.1016/s0962-8924(97)01172-0. Trends Cell Biol. 1998. PMID: 9695829 Review.
-
Tyrosine kinase signal transduction in rheumatoid synovitis.Semin Arthritis Rheum. 1992 Apr;21(5):317-29. doi: 10.1016/0049-0172(92)90025-9. Semin Arthritis Rheum. 1992. PMID: 1351318
Cited by
-
FAS(APO), DAMP, and AKT Phosphoproteins Expression Predict the Development of Nosocomial Infection After Pediatric Burn Injury.J Burn Care Res. 2024 Nov 14;45(6):1607-1616. doi: 10.1093/jbcr/irae111. J Burn Care Res. 2024. PMID: 38863248
-
Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients.J Inflamm (Lond). 2008 Apr 27;5:5. doi: 10.1186/1476-9255-5-5. J Inflamm (Lond). 2008. PMID: 18439312 Free PMC article.
-
Association of rheumatoid arthritis risk with EGFR genetic polymorphisms in Taiwan's Han Chinese population.Rheumatol Int. 2012 Aug;32(8):2301-6. doi: 10.1007/s00296-011-1961-4. Epub 2011 May 21. Rheumatol Int. 2012. PMID: 21604062
-
Differential phosphoprotein signaling in the cortex in mouse models of Gulf War Illness using corticosterone and acetylcholinesterase inhibitors.Heliyon. 2021 Jul 12;7(7):e07552. doi: 10.1016/j.heliyon.2021.e07552. eCollection 2021 Jul. Heliyon. 2021. PMID: 34307952 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
