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. 1973 Aug;70(8):2276–2280. doi: 10.1073/pnas.70.8.2276

Aminoglycoside Antibiotic-Inactivating Enzymes in Actinomycetes Similar to Those Present in Clinical Isolates of Antibiotic-Resistant Bacteria

Raoul Benveniste 1,*, Julian Davies 1,†
PMCID: PMC433717  PMID: 4209515

Abstract

Various species of Streptomyces possess aminoglycoside-modifying enzymes. Streptomyces kanamyceticus contains an enzyme that acetylates the 6′-amino group of kanamycin A and B, gentamicin C1a, and neomycin. Streptomyces spectabilis produces an enzyme that acetylates the 2′-amino group of the hexose ring of gentamicin C1a. These enzymes catalyze reactions identical to those catalyzed by enzymes found in gram-negative bacteria containing R(antibiotic resistance)-factors. The discovery of these enzymes suggests the possibility of an evolutionary relationship between the aminoglycosideinactivating enzymes (produced by resistance determinants) in bacteria containing R-factors and similar enzymes found in the actinomycetes.

Keywords: streptomyces, origin of R-factors, gentamicin-acetate

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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