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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1972 Jan;69(1):4–6. doi: 10.1073/pnas.69.1.4

Matching Sequences under Deletion/Insertion Constraints

David Sankoff 1
PMCID: PMC427531  PMID: 4500555

Abstract

Given two finite sequences, we wish to find the longest common subsequences satisfying certain deletion/insertion constraints. Consider two successive terms in the desired subsequence. The distance between their positions must be the same in the two original sequences for all but a limited number of such pairs of successive terms. Needleman and Wunsch gave an algorithm for finding longest common subsequences without constraints. This is improved from the viewpoint of computational economy. An economical algorithm is then elaborated for finding subsequences satisfying deletion/insertion constraints. This result is useful in the study of genetic homology based on nucleotide or amino-acid sequences.

Keywords: algorithm, genetic homology, nucleotide sequence, amino-acid sequence

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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