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. 1980 Feb;33(2):652–660. doi: 10.1128/jvi.33.2.652-660.1980

Association of endogenous retroviruses with radiation-induced leukemias of BALB/c mice.

R W Ellis, E Stockert, E Fleissner
PMCID: PMC288589  PMID: 6157834

Abstract

X-irradiation of BALB/c mice in the second month of life induced a high incidence of generalized lymphatic leukemia of T-cell origin, beginning at 7 months of age. Infectious ecotropic murine leukemia virus (B-tropic predominant over N-tropic) was isolable from all tumor extracts but exhibited a wide titer range among individual leukemias. Detection of infectious xenotropic virus usually required extensive amplification on indicator cells. Dual-tropic (mink cell focus-forming) virus has not been found in the leukemias. Expression of ecotropic virus in tail extracts prepared at 6.5 months of age, although greatly enhanced compared with unirradiated controls, was not found to be prognostic of tumor development in individual mice. We conclude that leukemogenesis does not show a simple dependence on infectious murine leukemia virus expression in these mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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