Abstract
Moulder, James W. (University of Chicago, Chicago, Ill.), Dorothy L. Novosel, and Julius E. Officer. Inhibition of the growth of agents of the psittacosis group by d-cycloserine and its specific reversal by d-alanine. J. Bacteriol. 85:707–711. 1963.—d-Cycloserine inhibited multiplication of four members of the psittacosis group in chick embryo yolk sac. d-Alanine reversed each inhibition. In infections with the agent of mouse pneumonitis, the most sensitive member of the psittacosis group tested, d-alanine competitively antagonized the growth inhibition produced by d-cycloserine. Of a number of other potential reversing agents, only dl-alanyl-dl-alanine reversed the effect of d-cycloserine on mouse pneumonitis agent. The significance of the susceptibility of the psittacosis group to d-cycloserine is discussed in light of the known mode of action of this antibiotic on bacteria.
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- BONDI A., KORNBLUM J., FORTE C. Inhibition of anitbacterial activity of cycloserine by alpha-alanine. Proc Soc Exp Biol Med. 1957 Oct;96(1):270–272. doi: 10.3181/00379727-96-23452. [DOI] [PubMed] [Google Scholar]
- JENKIN H. M. Preparation and properties of cell walls of the agent of meningopneumonitis. J Bacteriol. 1960 Nov;80:639–647. doi: 10.1128/jb.80.5.639-647.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JENKIN H. M., ROSS M. R., MOULDER J. W. Species-specific antigens from the cell walls of the agents of meningopneumonitis and feline pneumonitis. J Immunol. 1961 Feb;86:123–127. [PubMed] [Google Scholar]
- LITWIN J. A simple method for cultivation of viruses and rickettsiae in the chorio-allantoic ectoderm of the chick embryo by inoculation via the air sac. J Infect Dis. 1957 Jul-Aug;101(1):100–108. doi: 10.1093/infdis/101.1.100. [DOI] [PubMed] [Google Scholar]
- MOULDER J. W., COLON J. I., RUDA J., ZEBOVITZ M. M. The effect of penicillin on multiplying and nonmultiplying populations of sensitive and resistant strains of feline pneumonitis virus. J Infect Dis. 1956 May-Jun;98(3):229–238. doi: 10.1093/infdis/98.3.229. [DOI] [PubMed] [Google Scholar]
- MOULDER J. W., WEISS E. Purification and properties of the agent of feline pneumonitis. J Infect Dis. 1951 Jan-Feb;88(1):56–67. doi: 10.1093/infdis/88.1.56. [DOI] [PubMed] [Google Scholar]
- NEUHAUS F. C., LYNCH J. L. Studies on the inhibition of D-alanyl-D-alanine synthetase by the antibiotic D-cycloserine. Biochem Biophys Res Commun. 1962 Aug 7;8:377–382. doi: 10.1016/0006-291x(62)90011-6. [DOI] [PubMed] [Google Scholar]
- SHOCKMAN G. D. Reversal of cycloserine inhibition by D-alanine. Proc Soc Exp Biol Med. 1959 Aug-Sep;101:693–695. doi: 10.3181/00379727-101-25064. [DOI] [PubMed] [Google Scholar]
- WEISS E. The effect of antibiotics on agents of the psittacosis-lymphogranuloma group. I. The effect of penicillin. J Infect Dis. 1950 Nov-Dec;87(3):249–263. doi: 10.1093/infdis/87.3.249. [DOI] [PubMed] [Google Scholar]
- WELCH H., PUTNAM L. E., RANDALL W. A. Antibacterial activity and blood and urine concentrations of cycloserine, a new antibiotic, following oral administration. Antibiotic Med Clin Ther (New York) 1955 Feb;1(2):72–79. [PubMed] [Google Scholar]
- Zygmunt W. A. REVERSAL OF d-CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE. J Bacteriol. 1962 Jul;84(1):154–156. doi: 10.1128/jb.84.1.154-156.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]