Abstract
The recent identification of an endoplasmic reticulum-Golgi intermediate compartment has added to the complexity of the structural and functional organization of the early secretory pathway. Protein sorting along the endoplasmic reticulum-Golgi pathway depends on different signals and mechanisms, some of which guarantee recycling from various levels of the Golgi apparatus to biosynthetically earlier compartments.
Abbreviations: CGN—, cis-Golgi network; ER—, endoplasmic reticulum; ERGIC—, ER-Golgi intermediate compartment; MHC—, major histocompatibility complex; PDI—, protein disulphide isomerase; TEN—, trans-ER reticulum; TGN—, trans-Golgi reticumlum
References
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