Skip to main content
Springer Nature - PMC COVID-19 Collection logoLink to Springer Nature - PMC COVID-19 Collection
. 1981;68(1):35–44. doi: 10.1007/BF01315165

In vivo morphogenesis of a new porcine enteric coronavirus, CV 777

R Ducatelle 1, W Coussement 1, M B Pensaert 2, P Debouck 2, J Hoorens 1
PMCID: PMC7086781  PMID: 7247728

Summary

The morphogenesis of a new porcine enteric coronavirus, CV777, in intestinal epithelial cells of experimentally infected newborn piglets is described. The virus shows a morphogenetic pattern characteristic for members of the Coronaviridae family. It is formed by budding through membranes of the endoplasmic reticulum. Some specific aspects of this morphogenesis are discussed.

Keywords: Epithelial Cell, Infectious Disease, Endoplasmic Reticulum, Specific Aspect, Intestinal Epithelial Cell

Footnotes

With 9 Figures

References

  • 1.Becker W. B., McIntosh K., Dees J. H., Chanock R. M. Morphogenesis of Avian Infectious Bronchitis virus and a related human strain (strain 229 E) J. Virol. 1967;1:1019–1027. doi: 10.1128/jvi.1.5.1019-1027.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Bridger J. C., Caul E. O., Egglestone S. I. Replication of an enteric bovine coronavirus in intestinal organ cultures. Arch. Virol. 1978;57:43–51. doi: 10.1007/BF01315636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Bucknall R. A., Kalica A. R., Chanock R. M. Intracellular development and mechanism of hemadsorption of a human coronavirus, OC43. Proc. Exp. Biol. Med. 1972;139:811–817. doi: 10.3181/00379727-139-36243. [DOI] [PubMed] [Google Scholar]
  • 4.Coussement, W., Ducatelle, R., Debouck, P., Hoorens, J.: Pathology of experimental CV777 coronavirus enteritis in piglets. 1) Histological and histochemical study. Veterinary Pathology (to be published). [DOI] [PubMed]
  • 5.David H. Ortho- and pathomorphology of human and animal cells in drawings, diagrams and constructions. 1st ed. Stuttgart: Gustav Fischer Verlag; 1978. p. 128. [Google Scholar]
  • 6.David-Ferreirra J. F., Manaker R. A. An electron microscopic study of the development of a mouse hepatitis virus in tissue culture cells. J. Cell. Biol. 1965;24:57–78. doi: 10.1083/jcb.24.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Debouck P., Pensaert M. B. Experimental infection of pigs with a new porcine enteric coronavirus, CV777. Amer. vet. Res. 1980;41:219–223. [PubMed] [Google Scholar]
  • 8.Debouck, P., Pensaert, M., Coussement, W.: The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV777. Veterinary Microbiology (to be published).
  • 9.Doughri A. M., Storz J., Hajer I., Fernando H. S. Morphology and morphogenesis of a coronavirus infecting intestinal epithelial cells of newborn calves. Expt. mol. Pathol. 1976;25:355–370. doi: 10.1016/0014-4800(76)90045-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Doughri A. M., Storz J. Light and ultrastructural pathologic changes in intestinal coronavirus infection of newborn calves. Zbl. Vet. Med. 1977;B 24:367–385. doi: 10.1111/j.1439-0450.1977.tb01011.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Ducatelle, R., Coussement, W., Debouck, P., Hoorens, J.: Pathology of experimental CV777 coronavirus enteritis in piglets: 2) Electron microscopic study. Veterinary Pathology (to be published). [DOI] [PubMed]
  • 12.Hamre D., Kindig D. A., Mann J. Growth and intracellular development of a new respiratory virus. J. Virol. 1967;1:810–816. doi: 10.1128/jvi.1.4.810-816.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.McIntosh K. Coronaviruses: A comparative review. Curr. Top. Microbiol. Immunol. 1974;63:84–129. [Google Scholar]
  • 14.Oshiro L. S., Schieble J. H., Lennette E. H. Electron microscopic studies of coronavirus. J. gen. Virol. 1971;12:161–168. doi: 10.1099/0022-1317-12-2-161. [DOI] [PubMed] [Google Scholar]
  • 15.Pensaert M., Haelterman E. O., Hinsman E. J. Transmissible Gastroenteritis of swine: virus-intestinal cell interactions. II. Electron microscopy of the epithelium in isolated jejunal loops. Arch. ges. Virusforsch. 1970;31:335–351. doi: 10.1007/BF01253768. [DOI] [PubMed] [Google Scholar]
  • 16.Pensaert M., Debouck P. A new coronavirus-like particle associated with diarrhea in swine. Arch. Virol. 1978;58:243–247. doi: 10.1007/BF01317606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Pedersen N. C. Morphologic and physical characteristics of Feline Infectious Peritonitis virus and its growth in autochthonous peritoneal cell cultures. Amer. J. vet. Res. 1976;37:567–572. [PubMed] [Google Scholar]
  • 18.Storz J., Doughri A. M., Hajer I. Coronaviral morphogenesis and ultrastructural changes in intestinal infections of calves. J. A. V. M. A. 1978;173:633–635. [PubMed] [Google Scholar]
  • 19.Takeuchi A., Binn L. N., Jervis H. R., Keenan K. P., Hildebrandt P. K., Valas R. B., Bland F. F. Electron microscope study of experimental enteric infection in neonatal dogs with a canine coronavirus. Lab. Invest. 1976;34:539–549. [PubMed] [Google Scholar]
  • 20.Tyrrell D. A. J., Alexander D. J., Almeida J. D., Cunningham C. H., Easterday B. C., Garwes D. J., Hierholzer J. C., Kapikian A., Macnaughton M. R., McIntosh K. Coronaviridae: Second report. Intervirology. 1978;10:321–328. doi: 10.1159/000148996. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Virology are provided here courtesy of Nature Publishing Group

RESOURCES