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. 1990 Oct;87(20):8046–8050. doi: 10.1073/pnas.87.20.8046

Long-range movement and fibril association of type X collagen within embryonic cartilage matrix.

Q A Chen 1, E Gibney 1, J M Fitch 1, C Linsenmayer 1, T M Schmid 1, T F Linsenmayer 1
PMCID: PMC54889  PMID: 2236017

Abstract

A recent immunoelectron microscopic study of type X collagen in developing cartilage gave results that could be explained by movement of the molecule from one region of the cartilage matrix to another, there becoming associated with preexisting collagen fibrils. In the present study, to test the feasibility of this model we incubated pieces of nonhypertrophic, embryonic chicken sternal cartilage (which has no endogenous type X collagen) in medium with type X collagen and then used immunofluorescence and immunoelectron microscopy to evaluate movement of the molecule through the matrix. The results show that type X collagen molecules can indeed pass through embryonic sternal cartilage matrix and subsequently become fibril-associated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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