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. 1973 Apr;70(4):1017–1021. doi: 10.1073/pnas.70.4.1017

A Mutant Transcription Factor That is Activated by 3′:5′-Cyclic Guanosine Monophosphate

Richard Sanders 1,*, Duncan McGeoch 1
PMCID: PMC433415  PMID: 4352217

Abstract

We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli. Genetic data have indicated that the suppressor of the P- mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3′:5′-cyclic GMP in addition to their normal effector, 3′:5′-cyclic AMP.

Keywords: cAMP, catabolite activator protein, crp, promoter

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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