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. 1995 Nov 7;92(23):10792–10795. doi: 10.1073/pnas.92.23.10792

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

R D Miller 1, J Hogg 1, J H Ozaki 1, D Gell 1, S P Jackson 1, R Riblet 1
PMCID: PMC40698  PMID: 7479885

Abstract

The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.

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Selected References

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