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. 1984 Dec;81(24):7875–7879. doi: 10.1073/pnas.81.24.7875

Identification of a recent recombination event within the human beta-globin gene cluster.

D S Gerhard, K K Kidd, J R Kidd, J A Egeland, D E Housman
PMCID: PMC392255  PMID: 6096866

Abstract

In a detailed study of inheritance of DNA sequence polymorphism in a large reference pedigree, an individual was identified with an apparent genetic recombination event within the human beta-globin gene cluster. Analysis of the haplotypes of relevant individuals within this pedigree suggested that the meiotic crossing-over event is likely to have occurred within a 19.8-kilobase-pair region of the beta-globin gene cluster. Analysis of other DNA markers closely linked to the beta-globin gene cluster--segment 12 of chromosome 11 (D11S12) and loci for insulin, the cellular oncogene c-Ha-ras, and preproparathyroid hormone--confirmed that a crossover event must have occurred within the region of chromosome 11 between D11S12 and the beta-globin gene cluster. It is suggested that the event observed has occurred within a DNA region compatible with recombinational "hot spots" suggested by population studies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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