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. 1989 Sep 25;17(18):7315–7324. doi: 10.1093/nar/17.18.7315

Transcriptional trans-repression by the c-myb proto-oncogene product.

H Nakagoshi 1, T Nagase 1, Y Ueno 1, S Ishii 1
PMCID: PMC334811  PMID: 2552408

Abstract

We report that the c-myb protein binds to another site, MBS-II, in the SV40 enhancer with low affinity. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of the sequence containing the MBS-II site induced c-myb-dependent transcriptional repression. Results of mutational analyses of the sequence around the MBS-II site suggested that the c-myb protein represses transcription by competing with another trans-activator. These results indicate that c-myb protein can regulate transcription not only positively but also negatively.

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Selected References

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