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. 1988 May;85(9):2959–2963. doi: 10.1073/pnas.85.9.2959

Interaction of origin binding protein with an origin of replication of herpes simplex virus 1.

P Elias 1, I R Lehman 1
PMCID: PMC280122  PMID: 2834723

Abstract

Herpes simplex virus 1 encodes a protein that binds specifically to a viral DNA replication origin (oriS). This origin-binding protein has been purified to homogeneity by means of sequence-specific DNA affinity chromatography. The purified origin-binding protein, which has a molecular weight of 83,000, interacts with both parts of the oriS dyad; however, the affinity for the two sites differs by an order of magnitude. The sequence TTCGCA occurs as a nearly perfect direct repeat within the two sites and may constitute the recognition sequence for the origin-binding protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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