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. 1994 Dec;68(12):8461–8465. doi: 10.1128/jvi.68.12.8461-8465.1994

Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.

B Sherry 1, M A Blum 1
PMCID: PMC237323  PMID: 7966643

Abstract

Previously, we showed that the M1 gene (encoding a viral core protein, mu 2, whose function is unknown) was associated with the efficiently myocarditic phenotype of a reovirus variant, 8B. Here, we have extended our genetic analysis of 8B and conducted genetic analyses of two other reovirus strains (T1L [serotype 1 strain Lang] and Abney). Our results demonstrate that multiple viral core proteins are determinants of reovirus-induced myocarditis. In contrast to our previous association of mu 2 with induction of myocarditis, this provides strong evidence that a core function achieved through the interaction of multiple core proteins is responsible for induction of the disease.

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Selected References

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