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(A) Serum concentrations of interleukin10 (IL10) are increased immediately after infusion of polyclonal immunoglobulins for intravenous use (IVIg) in immunodeficient patients; (B) IVIg rapidly and strongly increase IL10 production in whole blood in vitro (one of seven experiments shown); (C) anti-FcR antibodies can inhibit IVIg induced IL10 production (one of three experiments shown).
