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. 1992 Jun;88(3):506–511. doi: 10.1111/j.1365-2249.1992.tb06479.x

Evidence for transfer of cellular and humoral immunity to cytomegalovirus from donor to recipient in allogeneic bone marrow transplantation.

G J Boland 1, A M Vlieger 1, C Ververs 1, G C De Gast 1
PMCID: PMC1554518  PMID: 1318805

Abstract

In order to study the importance of the immune status of the donor in the development of immunity after allogeneic bone marrow transplantation (BMT), we monitored 23 cytomegalovirus (CMV) antibody-positive BMT recipients for humoral and cellular immunity to CMV, of whom 12 had a CMV antibody-positive and 11 a CMV antibody-negative marrow donor. Lymphocyte proliferation to CMV recovered significantly earlier after BMT in recipients of marrow from a CMV+ donor (10.4 weeks after BMT) compared with the recipients of marrow from CMV- donors (16.7 weeks after BMT, P less than 0.05). This seemed to be specific, as lymphocyte proliferation to phytohaemagglutinin and Candida were not different between the to groups. IgM responses after active infection were seen in both groups, but initial IgG rises without IgM were seen only in recipients of marrow from CMV+ donors (P less than 0.05). Lymphocyte proliferative or humoral immune responses to CMV were not detected in any of the patients in a control group consisting of nine CMV- recipients. These results indicate that T cell memory to CMV is transferred with donor marrow from CMV+ donors, leading in most patients to direct IgG anti-CMV responses and to quicker recovery of cellular immunity to CMV.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boland G. J., de Gast G. C., Hené R. J., Jambroes G., Donckerwolcke R., The T. H., Mudde G. C. Early detection of active cytomegalovirus (CMV) infection after heart and kidney transplantation by testing for immediate early antigenemia and influence of cellular immunity on the occurrence of CMV infection. J Clin Microbiol. 1990 Sep;28(9):2069–2075. doi: 10.1128/jcm.28.9.2069-2075.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Duncombe A. S., Meager A., Prentice H. G., Grundy J. E., Heslop H. E., Hoffbrand A. V., Brenner M. K. Gamma-interferon and tumor necrosis factor production after bone marrow transplantation is augmented by exposure to marrow fibroblasts infected with cytomegalovirus. Blood. 1990 Sep 1;76(5):1046–1053. [PubMed] [Google Scholar]
  3. Einsele H., Vallbracht A., Friese M., Schmidt H., Haen M., Dopfer R., Niethammer D., Waller H. D., Ehninger G. Significant reduction of cytomegalovirus (CMV) disease by prophylaxis with CMV hyperimmune globulin plus oral acyclovir. Bone Marrow Transplant. 1988 Nov;3(6):607–617. [PubMed] [Google Scholar]
  4. Griffiths P. D., Panjwani D. D., Stirk P. R., Ball M. G., Ganczakowski M., Blacklock H. A., Prentice H. G. Rapid diagnosis of cytomegalovirus infection in immunocompromised patients by detection of early antigen fluorescent foci. Lancet. 1984 Dec 1;2(8414):1242–1245. doi: 10.1016/s0140-6736(84)92797-1. [DOI] [PubMed] [Google Scholar]
  5. Grob J. P., Grundy J. E., Prentice H. G., Griffiths P. D., Hoffbrand A. V., Hughes M. D., Tate T., Wimperis J. Z., Brenner M. K. Immune donors can protect marrow-transplant recipients from severe cytomegalovirus infections. Lancet. 1987 Apr 4;1(8536):774–776. doi: 10.1016/s0140-6736(87)92800-5. [DOI] [PubMed] [Google Scholar]
  6. Ljungman P., Wilczek H., Gahrton G., Gustavsson A., Lundgren G., Lönnqvist B., Ringdén O., Wahren B. Long-term acyclovir prophylaxis in bone marrow transplant recipients and lymphocyte proliferation responses to herpes virus antigens in vitro. Bone Marrow Transplant. 1986 Dec;1(2):185–192. [PubMed] [Google Scholar]
  7. Meyers J. D., Ljungman P., Fisher L. D. Cytomegalovirus excretion as a predictor of cytomegalovirus disease after marrow transplantation: importance of cytomegalovirus viremia. J Infect Dis. 1990 Aug;162(2):373–380. doi: 10.1093/infdis/162.2.373. [DOI] [PubMed] [Google Scholar]
  8. Quinnan G. V., Jr, Kirmani N., Esber E., Saral R., Manischewitz J. F., Rogers J. L., Rook A. H., Santos G. W., Burns W. H. HLA-restricted cytotoxic T lymphocyte and nonthymic cytotoxic lymphocyte responses to cytomegalovirus infection of bone marrow transplant recipients. J Immunol. 1981 May;126(5):2036–2041. [PubMed] [Google Scholar]
  9. Quinnan G. V., Jr, Kirmani N., Rook A. H., Manischewitz J. F., Jackson L., Moreschi G., Santos G. W., Saral R., Burns W. H. Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients. N Engl J Med. 1982 Jul 1;307(1):7–13. doi: 10.1056/NEJM198207013070102. [DOI] [PubMed] [Google Scholar]
  10. Schirm J., Timmerije W., van der Bij W., The T. H., Wilterdink J. B., Tegzess A. M., van Son W. J., Schröder F. P. Rapid detection of infectious cytomegalovirus in blood with the aid of monoclonal antibodies. J Med Virol. 1987 Sep;23(1):31–40. doi: 10.1002/jmv.1890230105. [DOI] [PubMed] [Google Scholar]
  11. Verdonck L. F., de Gast G. C. Is cytomegalovirus infection a major cause of T cell alterations after (autologous) bone-marrow transplantation? Lancet. 1984 Apr 28;1(8383):932–935. doi: 10.1016/s0140-6736(84)92391-2. [DOI] [PubMed] [Google Scholar]
  12. Verdonck L. F., de Gast G. C., van Heugten H. G., Dekker A. W. A fixed low number of T cells in HLA-identical allogeneic bone marrow transplantation. Blood. 1990 Feb 1;75(3):776–780. [PubMed] [Google Scholar]
  13. Verdonck L. F., van Heugten H., de Gast G. C. Delay in platelet recovery after bone marrow transplantation: impact of cytomegalovirus infection. Blood. 1985 Oct;66(4):921–925. [PubMed] [Google Scholar]
  14. Verdonck L. F., van der Linden J. A., Bast B. J., Gmelig Meyling F. H., de Gast G. C. Influence of cytomegalovirus infection on the recovery of humoral immunity after autologous bone marrow transplantation. Exp Hematol. 1987 Sep;15(8):864–868. [PubMed] [Google Scholar]
  15. Wimperis J. Z., Brenner M. K., Prentice H. G., Reittie J. E., Karayiannis P., Griffiths P. D., Hoffbrand A. V. Transfer of a functioning humoral immune system in transplantation of T-lymphocyte-depleted bone marrow. Lancet. 1986 Feb 15;1(8477):339–343. doi: 10.1016/s0140-6736(86)92315-9. [DOI] [PubMed] [Google Scholar]
  16. Wimperis J. Z., Brenner M. K., Prentice H. G., Thompson E. J., Hoffbrand A. V. B cell development and regulation after T cell-depleted marrow transplantation. J Immunol. 1987 Apr 15;138(8):2445–2450. [PubMed] [Google Scholar]
  17. de Gast G. C., Gratama J. W., Verdonck L. F., van Heugten J. G., Zwaan F. E., Phillips D. I., Mudde G. C. The influence of T cell depletion on recovery of T cell proliferation to herpesviruses and Candida after allogeneic bone marrow transplantation. Transplantation. 1989 Jul;48(1):111–115. doi: 10.1097/00007890-198907000-00026. [DOI] [PubMed] [Google Scholar]

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