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. 1974 Jan;26(1):49–60.

Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes

R E Cone, M Feldmann, J J Marchalonis, G J V Nossal
PMCID: PMC1423108  PMID: 4546381

Abstract

The cytophilic properties of released surface immunoglobulins of normal thymus lymphocytes and of activated thymus-derived lymphocytes (ATC) were analysed by lactoperoxidase-catalysed radioiodination in conjunction with immunological and autoradiographic techniques. Immunoglobulin from both normal T cells and ATC was cytophilic for macrophages (peritoneal exudate cells), but showed no detectable capacity to bind to either T lymphocytes or to bone-marrow-derived lymphocytes (B cells). Under the operative experimental conditions surface immunoglobulin of B cells did not show appreciable binding to macrophages. These results support the feasibility of models of collaboration between T cells and B cells which involve a soluble antigen-specific collaborative factor (T-cell Ig complexed with antigen) and show an obligatory requirement for macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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