Entry - *603889 - SIGNAL REGULATORY PROTEIN, BETA-1; SIRPB1 - OMIM

 
 
* 603889

SIGNAL REGULATORY PROTEIN, BETA-1; SIRPB1


HGNC Approved Gene Symbol: SIRPB1

Cytogenetic location: 20p13   Genomic coordinates (GRCh38) : 20:1,561,385-1,620,009 (from NCBI)


▼ TEXT

Signaling through receptor tyrosine kinases (RTKs) regulates the growth of many cell types. The transmembrane protein SIRP-alpha-1 (602461) is a substrate of activated RTKs and binds to SH2 domains. Kharitonenkov et al. (1997) defined 2 subfamilies of SIRPs (signal regulatory proteins). Members of the SIRP-alpha subfamily have a cytoplasmic SHP2-binding domain; members of the SIRP-beta subfamily lack this cytoplasmic tail. Kharitonenkov et al. (1997) cloned 4 homologous SIRP genes. The SIRP-beta-1 gene encodes a 398-amino acid polypeptide which lacks the C-terminal SHP2-binding cytoplasmic domain.


▼ REFERENCES

  1. Kharitonenkov, A., Chen, Z., Sures, I., Wang, H., Schilling, J., Ullrich, A. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386: 181-186, 1997. [PubMed: 9062191, related citations] [Full Text]


Creation Date:
Jennifer P. Macke : 6/8/1999
Edit History:
carol : 12/27/2001
carol : 12/11/2000
alopez : 6/8/1999

* 603889

SIGNAL REGULATORY PROTEIN, BETA-1; SIRPB1


HGNC Approved Gene Symbol: SIRPB1

Cytogenetic location: 20p13   Genomic coordinates (GRCh38) : 20:1,561,385-1,620,009 (from NCBI)


TEXT

Signaling through receptor tyrosine kinases (RTKs) regulates the growth of many cell types. The transmembrane protein SIRP-alpha-1 (602461) is a substrate of activated RTKs and binds to SH2 domains. Kharitonenkov et al. (1997) defined 2 subfamilies of SIRPs (signal regulatory proteins). Members of the SIRP-alpha subfamily have a cytoplasmic SHP2-binding domain; members of the SIRP-beta subfamily lack this cytoplasmic tail. Kharitonenkov et al. (1997) cloned 4 homologous SIRP genes. The SIRP-beta-1 gene encodes a 398-amino acid polypeptide which lacks the C-terminal SHP2-binding cytoplasmic domain.


REFERENCES

  1. Kharitonenkov, A., Chen, Z., Sures, I., Wang, H., Schilling, J., Ullrich, A. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386: 181-186, 1997. [PubMed: 9062191] [Full Text: https://doi.org/10.1038/386181a0]


Creation Date:
Jennifer P. Macke : 6/8/1999

Edit History:
carol : 12/27/2001
carol : 12/11/2000
alopez : 6/8/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 5, 2024