Skip to main content
Springer Nature Link
Log in

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

Introduction

  • The ABC of Solute Carriers
  • Published:
Pflügers Archiv Aims and scope Submit manuscript

Abstract

The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl.ac.uk/nomenclature/). Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established (http://www.pharmaconference.org/slctable.asp) that gives the latest updates for the SLC families and their members as well as relevant links to gene databases and reviews in the literature. A list of all currently known SLC families, a discussion of additional SLC families and family members as well as a brief summary of non-SLC transporter genes is included in this introduction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Armstrong CM (2003) Voltage-gated K channels. Sci STKE 188:re10

    Google Scholar 

  2. Babu E, Kanai Y, Chairoungdua A, Kim DK, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S, Anzai N, Nagamori S, Endou H (2003) Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem 278:43838–43845

  3. Borst P, Elferink RO (2002) Mammalian ABC transporters in health and disease. Annu Rev Biochem 71:537–592

    Google Scholar 

  4. Chen TY (2003) Coupling gating with ion permeation in ClC channels. Sci STKE 2003:e23

    Google Scholar 

  5. Cox DW, Moore SD (2002) Copper transporting P-type ATPases and human disease. J Bioenerg Biomembr 34:333–338

    Article  CAS  PubMed  Google Scholar 

  6. DeCoursey TE (2003) Voltage-gated proton channels and other proton transfer pathways. Physiol Rev 83:475–579

    CAS  PubMed  Google Scholar 

  7. Dunbar LA, Caplan MJ (2000) The cell biology of ion pumps: sorting and regulation. Eur J Cell Biol 79:557–563

    CAS  PubMed  Google Scholar 

  8. Gunther W, Piwon N, Jentsch TJ (2003) The ClC-5 chloride channel knock-out mouse—an animal model for Dent’s disease. Pflugers Arch 445:456–462

    CAS  PubMed  Google Scholar 

  9. Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R (2003) The principle of gating charge movement in a voltage-dependent K+ channel. Nature 423:42–48

    Article  CAS  PubMed  Google Scholar 

  10. Muller V, Gruber G (2003) ATP synthases: structure, function and evolution of unique energy converters. Cell Mol Life Sci 60:474–494

    CAS  PubMed  Google Scholar 

  11. O’Regan S, Meunier FM (2003) Selection and characterization of the choline transport mutation suppressor from Torpedo electric lobe, CTL1. Neurochem Res 28:551–555

    Article  CAS  PubMed  Google Scholar 

  12. O’Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (2000) An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. Proc Natl Acad Sci USA 97:1835–1840

    Article  CAS  PubMed  Google Scholar 

  13. Peng JB, Brown EM, Hediger MA (2003) Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. J Physiol (Lond) 551:729–740

  14. Romero MF, Kanai Y, Gunshin H, Hediger MA (1998) Expression cloning using Xenopus laevis oocytes. Methods Enzymol 296:17–52

    CAS  Google Scholar 

  15. Smith RL, Thompson LJ, Maguire ME (1995) Cloning and characterization of MgtE, a putative new class of Mg2+ transporter from Bacillus firmus OF4. J Bacteriol 177:1233–1238

    CAS  PubMed  Google Scholar 

  16. Townsend DE, Esenwine AJ, George J III, Bross D, Maguire ME, Smith RL (1995) Cloning of the MgtE Mg2+ transporter from Providencia stuartii and the distribution of MgtE in gram-negative and gram-positive bacteria. J Bacteriol 177:5350–5354

    CAS  PubMed  Google Scholar 

  17. Uhl J, Penzel R, Sergi C, Kopitz J, Otto HF, Cantz M (2002) Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient. FEBS Lett 521:19–23

    Article  CAS  PubMed  Google Scholar 

  18. Wabakken T, Rian E, Kveine M, Aasheim HC (2003) The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Biochem Biophys Res Commun 306:718–724

    Article  CAS  PubMed  Google Scholar 

  19. Yu FH, Catterall WA (2003) Overview of the voltage-gated sodium channel family. Genome Biol 4:207

    Article  PubMed  Google Scholar 

  20. Ishida N, Kawakita M (2003) Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch (in press)

  21. Hagenbuch B, Meier PJ (2003) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch (in press)

Download references

Author information

Authors and Affiliations

  1. Membrane Biology Program and Renal Division, Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA

    Matthias A. Hediger & Hitomi Takanaga

  2. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4970, USA

    Michael F. Romero

  3. Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA

    Ji-Bin Peng

  4. Harvard Institute of Proteomics, Harvard Medical School, Cambridge, MA 02141, USA

    Andreas Rolfs

  5. HUGO Gene Nomenclature Committee, Department of Biology, University College London, London, NW1 2HE, UK

    Elspeth A. Bruford

Authors
  1. Matthias A. Hediger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael F. Romero
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ji-Bin Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andreas Rolfs
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hitomi Takanaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Elspeth A. Bruford
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matthias A. Hediger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hediger, M.A., Romero, M.F., Peng, JB. et al. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflugers Arch - Eur J Physiol 447, 465–468 (2004). https://doi.org/10.1007/s00424-003-1192-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00424-003-1192-y

Keywords

Search

Navigation