Summary
The pathogenetic factors of postmenopausal and senile osteoporosis are reviewed. Both postmenopausal and senile osteoporosis occur as a result of a defective regulation of bone remodelling which leads to a negative uncoupling between bone resorption and bone formation. Systemic and local factors contribute to the development of the phenomenon. While studies of the systemic factors involved in age-related bone loss are well advanced, although still incomplete, the study of the local factors responsible at a tissue level for the negative skeletal balance has barely begun.
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Mazzuoli, G.F., D'erasmo, E., Minisola, S. et al. Pathogenethic aspects of involutional osteoporosis. Clin Rheumatol 8 (Suppl 2), 22–29 (1989). https://doi.org/10.1007/BF02207229
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DOI: https://doi.org/10.1007/BF02207229