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The carboxylate type siderophore rhizoferrin and its analogs produced by directed fermentation

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Journal of Industrial Microbiology

Summary

Rhizoferrin is a novel carboxylate-type siderophore which has recently been isolated fromRhizopus microsporus and other fungi of the Mucorales (Zygomycetes). The present investigation shows that a variety of rhizoferrin analogs can be produced by directed fermentation. Thus both the diaminobutane backbone and the citric acid side chains of rhizoferrin have been substituted by diamine and citric acid analogs added to the culture medium. The new ligands as well as their iron complexes have been characterized by physicochemical methods. Conditions of precursor incorporation and implications for the biosynthesis of the new siderophores are discussed.

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Authors and Affiliations

  1. Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, Germany

    H. Drechsel & G. Jung

  2. Intitute of Biology, Microbiology and Biotechnology, University of Tübingen, Auf der Morgenstelle 1, 72076, Tübingen, Germany

    M. Tschierske, A. Thieken, H. Zähner & G. Winkelmann

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  1. H. Drechsel
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  2. M. Tschierske
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  3. A. Thieken
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  4. G. Jung
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  5. H. Zähner
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  6. G. Winkelmann
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Drechsel, H., Tschierske, M., Thieken, A. et al. The carboxylate type siderophore rhizoferrin and its analogs produced by directed fermentation. Journal of Industrial Microbiology 14, 105–112 (1995). https://doi.org/10.1007/BF01569891

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