Summary
In iron free cultures Pseudomonas fluorescens secretes a polypeptide which reacts with ferric ions to form a stable complex. This iron complex called Ferribactin is a dihydroxamate and belongs to the Siderochromes. Ferribactin contains at least the following components: A mole each of glycine, L-serine, d-serine, L-glutamic acid, δ-N-hydroxy-L-ornithine, δ-N-hydroxy-d-ornithine, d-tyrosine, 3 moles of L-lysine and 2 moles of acetic acid.
Zusammenfassung
Pseudomonas fluorescens scheidet bei Anzucht unter Eisenmangel ein Polypeptid in die Nährlösung aus, das mit Ferri-Ionen einen stabilen Komplex bildet. Dieser Eisenkomplex, Ferribactin genannt, stellt ein Dihydroxamat dar und gehört zu den Siderochromen. Ferribactin enthält mindestens die folgenden Bausteine: Je 1 Mol Glycin, L-Serin, d-Serin, L-Glutaminsäure, δ-N-Hydroxy-L-ornithin, δ-N-Hydroxy-d-ornithin, d-Tyrosin, 3 Mol L-Lysin und 2 Mol Essigsäure.
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Literatur
Burnham, B. F., and J. B. Neilands: Studies on the metabolic function of the ferrichrome compounds. J. biol. Chem. 236, 554 (1961).
Burton, M. O., F. J. Sowden, and A. G. Lochhead: Studies on the isolation and nature of the “terregens factor”. Canad. J. Biochem. 32, 400 (1954).
Byers, B. R., M. V. Powell, and C. E. Lankford: Iron-chelating hydroxamic acid (Schizokinen) active in initiation of cell division in Bacillus megaterium. J. Bact. 93, 286 (1967).
Dutta, R. L.: Metal complexes of hydroxamic acids. Colored complexes of iron, vanadium and molybdenum with isonicotinohydroxamic acids and their analytical uses. J. Ind. chem. Soc. 36, 285 (1959).
Emery, T.: Isolation, characterization and properties of fusarinine, a delta hydroxamic acid derivative of ornithine. Biochemistry 4, 1410 (1965).
Hesseltine, C. W., A. R. Whitehill, C. Pidacks, M. T. Hagen, N. Bohonos, B. L. Hutchings, and J. H. Williams: Coprogen, a new growth factor present in dung, required by Pilobolus kleinii: Mycologia (N.Y.) 45, 7 (1953).
Eller-Schierlein, W.: Stoffwechselprodukte von Mikroorganismen, 45. Mitt. Über die Konstitution von Ferrirubin, Ferrirhodin und Ferrichrom A. Helv. chim. Acta 46, 1920 (1963).
—, u. A. Deér: Stoffwechselprodukte von Mikroorganismen, 44. Mitt. Zur Konstitution von Ferrichrysin und Ferricrocin. Helv. chim. Acta 46, 1907 (1963).
— u. H. Zähner: Siderchrome [Natürliche Eisen(III)-trihydroxamat-Komplexe]. Fortschr. chem. organ. Naturst. 22, 279 (1964).
Neilands, J. B.: Some aspects of microbial iron metabolism. Bact. Rev. 21, 101 (1957).
—: Naturally occuring non-porphyrin iron compounds. Structure and Bonding, Vol. I, p. 59. Berlin-Heidelberg-New York: Springer 1966.
Sandell, E. B.: Chemical Analysis, Vol. 3: Chemical Determination of Traces of Metals, 3rd Ed., p. 523. New York: Interscience Publishers, Inc. 1958.
Schroeder, W. A., and L. R. Honnen: Correlation between the structure of some dinitrophenyl peptides and their chromatographic behavior on silicic acid-celite. J. Amer. chem. Soc. 75, 4615 (1953).
Shiman Ross, and J. B. Neilands: Isolation, characterization and synthesis of pyrimine, an iron(II)-binding agent from Pseudomonas GH. Biochemistry 4, 2233 (1965).
Simon, W., E. Kovats, L. H. Chopard-dit-Jean u. E. Heilbronner: Zur Mikrotitration organischer Verbindungen; Teil I: Halbautomatische Apparatur zur Mikrotitration. Helv. chim. Acta 37, 1872 (1954).
Snow, G. A.: Mycobactin. A growth factor for Mycobacterium johnei, Part. III. Degradation and tentative structure. J. chem. Soc. 1954, 4080.
—: The structure of mycobactin P, a growth factor for Mycobacterium johnei, and the significance of its iron complex. Biochem. J. 94, 160 (1965).
—: Isolation and structure of mycobactin T, a growth factor from Mycobacterium tuberculosis. Biochem. J. 97, 166 (1965).
Wetlaufer, D. B., J. T. Edsall, and B. R. Hollingworth: Ultraviolet difference spectra of tyrosine groups in proteins and amino acids. J. biol. Chem. 233, 1421 (1958).
Zähner, H., R. Hütter u. E. Bachmann: Stoffwechselprodukte von Actinomyceten, 23. Mitt. Zur Kenntnis der Sideromycinwirkung. Arch. Mikrobiol. 36, 325 (1960).
— u. A. Deér: Stoffwechselprodukte von Mikroorganismen, 40. Mitt. Sideramine aus Aspergillaceen. Arch. Mikrobiol. 45, 119 (1963).
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60. Mitt.: Gerlach, H., u. E. Huber: Synthese der 8-Desoxynonactinsäure. Helv. chim. Acta 50, 2087–2090 (1967).
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Maurer, B., Müller, A., Keller-Schierlein, W. et al. Stoffwechselprodukte von Mikroorganismen. Archiv. Mikrobiol. 60, 326–339 (1968). https://doi.org/10.1007/BF00408553
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DOI: https://doi.org/10.1007/BF00408553