Summary
We describe the presence of a high frequency of spontaneous chromosome aberrations in lymphocytes from six untreated patients with Hodgkin's disease. The characteristics of the chromosome abnormalities observed suggest the existence of a certain degree of chromosome instability in these cases, that could be a predisposing factor for the development of malignancies.
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Barrios, L., Caballín, M.R., Mirò, R. et al. Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. Hum Genet 78, 320–324 (1988). https://doi.org/10.1007/BF00291727
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DOI: https://doi.org/10.1007/BF00291727