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Human tumor xenografts as model for drug testing

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Abstract

This paper reviews the history of xenografts, the endpoints commonly used to evaluate response and chemotherapeutic results obtained with serially maintained human tumor xenografts from different laboratories, and discusses the potential clinical relevance of the heterotransplant model for cancer chemotherapy. Specifically, an attempt is made to correlate the published xenograft data with the clinical data. Drug testing with different types of xenotransplanted tumors has shown that the response of xenografts obtained in immune-deficient animals is comparable to that in clinical practice. In addition, xenografts of a particular tumor type are able to identify agents of known clinical activity against that disease.

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References

  1. Adams RA, Flowers A, Sundeen R, Merk LP: Chemotherapy and immunotherapy of three human lymphomas serially transplantable in the neonatal syrian hamster. Cancer 29: 524–533, 1972

    Google Scholar 

  2. Bailey MJ, Smith IE: Correlation between experimentally and clinically demonstrated activity of two new cytotoxic agents in breast cancer. Anticancer Res 5: 419–422, 1985

    Google Scholar 

  3. Bailey MJ, Gazet JC, Peckham MJ: Human breast-cancer xenografts in immune-suppressed mice. Br J Cancer 42: 524–529, 1980

    Google Scholar 

  4. Bailey MJ, Gazet JC, Smith IE, Steel GG: Chemotherapy of human breast-carcinoma xenografts. Br J Cancer 42: 530–536, 1980

    Google Scholar 

  5. Bailey MJ, Jones AJ, Shorthouse AJ, Raghaven D, Selby P, Gibbs J, Peckham MJ: Limitations of the human tumour xenograft system in individual patient drug sensitivity testing. Br J Cancer 50: 721–724, 1984

    Google Scholar 

  6. Bailey MJ, Ormerod MG, Imrie SF, Humphreys J, Roberts JDB, Gazet JC, Neville AM: Comperative functional histopathology of human breast carcinoma xenografts. Br J Cancer 43: 125–134, 1981

    Google Scholar 

  7. Basler GA, Shapiro WR: Brain tumor research with nude mice. In: Fogh J, Giovanella BC (eds) The Nude Mouse in Experimental and Clinical Research, Vol 2. New York: Academic Press, 1982, pp 475–490

    Google Scholar 

  8. Bastert G, Fortmeyer HP, Eichholz H, Michel RT, Huck R, Schmidt-Matthiesen H: Human breast cancer in thymusplastic mice. In: Bastert G, Fortmeyer HP, Schmidt-Matthiesen H (eds) Thymusaplastic Nude Mice and Rats in Clinical Oncology. Stuttgart: G. Fischer-Verlag, 1981, pp 157–182

    Google Scholar 

  9. Benedict WF, Dawson JA, Banerjee A, Murphree AL: The nude mouse model for human retinoblastoma: a system for evaluation of retinoblastoma therapy. Med Pediatr Oncol 8: 391–395, 1980

    Google Scholar 

  10. Berenbaum MC, Sheard CE, Reittie JR, Bundick RV: The growth of human tumours in immune-suppressed mice and their response to chemotherapy. Br J Cancer 30: 13–32, 1974

    Google Scholar 

  11. Boven E, Nauta MM, Schluper HMM, Elferink F, Van der Vijgh JF, Pinedo HM: Secondary screening of platinum compounds in human ovarian cancer xenografts in nude mice. Eur J Cancer 21: 1253–1260, 1985

    Google Scholar 

  12. Braakhuis BJM, Nauta MM, Romijn JC, Rutgers DH, Smink T: Enhanced success rate of transplantation with human tumors in cyclophosphamide-treated nude mice. J Natl Cancer Inst 76: 241–245, 1986

    Google Scholar 

  13. Braakhuis BJM, Schoevers EJ, Heinerman ECM, Sneeuwloper G, Snow GB: Chemotherapy of human head and neck cancer xenografts with three clinically active drugs: cis-platinum, bleomycin and methotrexate. Br J Cancer 48: 711–716, 1983

    Google Scholar 

  14. Burg-Kurland CL, Purnell DM, Combs JW, Valerio MG, Harris CC, Trump BF: Immunocytochemical evaluation of primary human esophageal carcinomas and their xenografts for keratin, β-chorionic ganadotropin, placental lactogen, α-fetoprotein, carcinoembryonic antigen, and nonspecific cross-reacting antigen. Cancer Res 46: 5730–5737, 1986

    Google Scholar 

  15. Clarysse A, Kenis Y, Mathé G: (eds) Cancer Chemotherapy. Heidelberg: Springer-Verlag, 1976

    Google Scholar 

  16. Cobb LM: The behaviour of carcinoma of the large bowel in man following transplantation into immune deprived mice. Br J Cancer 28: 400–411, 1973

    Google Scholar 

  17. Cobb LM, Mitcheley BCV: The growth of human tumours in immune deprived mice. Eur J Cancer 10: 473–476, 1974

    Google Scholar 

  18. Davy M, Brustad T, Mossige J: Irradiation of human ovarian tumors in nude mice. In: Numura T, Ohsawa N, Tamaoki N, Fujiwara K (eds) Proceedings of the Second International Workshop on Nude Mice. Stuttgart: G. Fischer-Verlag, 1977, pp 491–498

    Google Scholar 

  19. Double JA, Ball CR: Influence of transplantation site on the establishment of human tumour xenografts in immunosuppressed mice. Br J Cancer 31: 261–265, 1975

    Google Scholar 

  20. Engelholm SA, Spang-Thomsen M, Vindelov LL, Bruenner N: Effect of melphalan on growth curves and cell cycle distribution of four human small cell carcinomas of the lung grown in nude mice. Expl Cell Biol 54: 138–148, 1986

    Google Scholar 

  21. Engelholm SA, Spang-Thomsen M, Vindelov LL, Bruenner N, Nielsen MH, Hirsch F, Nielsen A, Hansen HH: Comparison of characteristics of human small cell carcinoma of the lung in patients, in vitro and transplanted into nude mice. Acta Path Microbiol Immunol Scand Sect A 94: 325–336, 1986

    Google Scholar 

  22. Evans BD, Smith IE, Shorthouse AJ, Millar JL: A comparison of the response of human lung carcinoma xenografts to vindesine and vincristine. Br J Cancer 45: 466–468, 1982

    Google Scholar 

  23. Fidler IJ: Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Met rev 5: 29–49, 1986

    Google Scholar 

  24. Fiebig HH, Schuchhardt C, Henss H, Fiedler L, Löhr GW: Comparison of tumor response in nude mice and in the patients. Behring Inst Mitt 74: 343–352, 1984

    Google Scholar 

  25. Fiebig HH, Widmer KH, Fiedler L, Wittekind C, Löhr GW: Development and characterization of 51 human tumor models for large bowel, stomach and esophageal cancers. Dig Surg 1: 225–235, 1984

    Google Scholar 

  26. Flanagan SP: ‘Nude’, a hairless gene with pleiotropic effects in the mouse. Genet Res Camb 8: 295–309, 1966

    Google Scholar 

  27. Fodstad O, Aass N, Pihl A: Response to chemotherapy of human malignant melanoma xenografts in athymic, nude mice. Int J Cancer 25: 453–458, 1980

    Google Scholar 

  28. Fogh J, Fogh JM, Orfeo T: One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59: 221–225, 1977

    Google Scholar 

  29. Fogh J, Orfeo T, Tiso J, Sharkey FE: Establishment of human colon carcinoma lines in nude mice. Exp Cell Biol 47: 136–144, 1979

    Google Scholar 

  30. Fogh J, Orfeo T, Tiso J, Sharkey FE, Fogh JM, Daniels WP: Twenty-three new human tumor lines established in nude mice. Exp Cell Biol 48: 229–239, 1980

    Google Scholar 

  31. Fogh J, Tiso J, Orfeo T, Sharkey FE, Daniels WP, Fogh JM: Thirty-four lines of six human tumor categories established in nude mice. J Natl Cancer Inst 64: 745–751, 1980

    Google Scholar 

  32. Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE: Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep 50: 219–244, 1966

    Google Scholar 

  33. Freudenthal RI, Lebel AP, Emmerling DC, Kerchner GA, Ovejera AA: Comparison of the drug metabolizing enzymes in the liver and kidneys from homozygous nude Swiss, heterozygous normal Swiss, homozygous normal Swiss and DBA/2 mice. Res Commun Chem Pathol Pharmacol 15: 267–278, 1976

    Google Scholar 

  34. Friedlander ML, Russell P, Taylor IW, Tattersall MHN: Ovarian tumor xenografts in the study of the biology of human epithelial ovarian cancer. Br J Cancer 51: 319–333, 1985

    Google Scholar 

  35. Friedman HS, Schold SC, Bigner DD: Chemotherapy of subcutaneous and intracranial human medulloblastoma xenografts in athymic nude mice. Cancer Res 46: 224–228, 1986

    Google Scholar 

  36. Friedman HS, Schold SC, Varia M, Bigner DD: Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. Cancer Res 43: 3088–3093, 1983

    Google Scholar 

  37. Fujita M, Hayata S, Taguchi T: Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient. J Surg Oncol 15: 211–219, 1980

    Google Scholar 

  38. Gallie L, Albert DM, Wong JJY, Buyukmihci N, Puliafito CA: Heterotransplantation of retinoblastoma into the athymic “nude” mouse. Invest Ophthalmol Visual Sci 16: 256–259, 1977

    Google Scholar 

  39. Gazdar AF, Carney DN, Sims HL, Simmons A: Heterotransplantation of small-cell carcinoma of the lung into nude mice: comparison of intracranial and subcutaneous routes. Int J Cancer 28: 777–783, 1981

    Google Scholar 

  40. Geran RI, Greenberg NH, MacDonald MM, Schumacher AM, Abbott BJ: Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep Part 3: 51–60, 1972

    Google Scholar 

  41. Gershwin ME, Ikeda RM, Erickson K, Owens R: Enhancement of heterotransplanted human tumor graft survival in nude mice treated with antilymphocyte serum and in congenitally athymic-asplenic (lasat) mice. J Natl Cancer Inst 61: 245–248, 1978

    Google Scholar 

  42. Giovanella BC, Stehlin JS, Shepard RC: Experimental chemotherapy of human breast carcinomas heterotrans-planted in nude mice. In: Noruma T, Ohsawa N, Tamaoki N, Fujiwara K (eds) Proceedings of the Second International Workshop on Nude Mice. Stuttgart: G. Fischer-Verlag, 1977, pp 475–481

    Google Scholar 

  43. Giovanella BC, Stehlin JS, Fogh J, Sharkey F: Serial transplantation of human malignant tumors in nude mice and their use in experimental chemotherapy. In: Houchens DP, Ovejera AA (eds) Proceedings of the Symposium on the Use of Athymic (Nude) Mice in Cancer Research. Stuttgart: G. Fischer-Verlag, 1978, pp 163–179

    Google Scholar 

  44. Giovanella BC, Shepard RC, Stehlin JS, Venditti JM, Abbott BJ: Calorie restriction: Effect on growth of human tumors heterotransplanted in nude mice. J Natl Cancer Inst 68: 249–257, 1982

    Google Scholar 

  45. Giovanella BC, Stehlin JS, Williams LJ, Lee SS, Shepard RC: Heterotransplantation of human cancers into nude mice. A model system for human cancer chemotherapy. Cancer 42: 2269–2281, 1978

    Google Scholar 

  46. Gisler RH, Schuhmann G, Dukor P: Functional characteristics of lymphocyte populations from nude mice: requirements for antibody-formation in vitro. In: Rygaard J, Povlsen CO (eds) Proceedings of the First International Workshop on Nude Mice. Stuttgart: G. Fischer-Verlag, 1974, pp 77–87

    Google Scholar 

  47. Giuliani FC, Kaplan NO: New doxorubicin analogs active against doxorubicin-resistant colon tumor xenografts in the nude mouse. Cancer Res 40: 4682–4687, 1980

    Google Scholar 

  48. Giuliani FC, Zirvi KA, Kaplan NO: Therapeutic response of human tumor xenografts in athymic mice to doxorubicin. Cancer Res 41: 325–335, 1981

    Google Scholar 

  49. Giuliani FC, Zirvi KA, Kaplan NO, Goldin A: Chemotherapy of human colorectal tumor xenografts in athymic mice with clinically active drugs: 5-fluorouracil and 1–3-bis (-2-chloroethyl)-1-nitrosourea (BCNU). Comparison with doxorubicin derivates: 4′ deoxydoxorubicin and 4′-O-methyldoxorubicin. Int J Cancer 27: 5–13, 1981

    Google Scholar 

  50. Goldenberg DM, Pavia RA: In vivo horizontal oncogenesis by a human tumor in nude mice. Proc Natl Acad Sci 79: 2389–2392, 1982

    Google Scholar 

  51. Goldenberg DM, Witte S: Chemotherany of two morphologically similar human tumors growing in the cheekpouch of the golden hamster. H Ad No 1 and GW-39. Eur J Cancer 3: 95–101, 1967

    Google Scholar 

  52. Greene HSN: The significance of the heterologous transplantability of human cancer. Cancer 5: 24–44, 1952

    Google Scholar 

  53. Hanatani Y, Kubota T, Yamada Y, Tsuyuki K, Nakada M, Matsumoto S, Kumai K, Yoshino K, Ishibiki K, Abe O: Experimental chemotherapy of human carcinomas serially transplanted to nude mice. J Jap Soc Cancer Ther 15: 1114–1120, 1980

    Google Scholar 

  54. Hanna N: Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural killer cell-mediated cytoxicity. Int J Cancer 26: 675–680, 1980

    Google Scholar 

  55. Hanna N, Davis TW, Fidler IJ: Environmental and genetic factors determine the level of NK activity of nude mice and affect their suitability as models for experimental metastasis. Int J Cancer 30: 371–376, 1982

    Google Scholar 

  56. Hayashi H, Kameya T, Shimosato Y, Mukojima T: Chemotherapy of human choriocarcinoma tranplanted to nude mice. Am J Obstet Gynecol 131: 548–554, 1978

    Google Scholar 

  57. Hoehn W, Schroeder FH, Riemann JF, Joebsis AC, Hermanek P: Human prostatic adenocarcinoma: some characteristics of a serially transplantable line in nude mice (PC82). Prostate 1: 95–104, 1980

    Google Scholar 

  58. Hori T, Matsui T, Matsutani M, Terao H, Teramoto S, Takakura K: Experimental therapy of human oligoden-droglioma transplanted into nude mice and its clinical trial in the donor. Jpn J Clin Oncol 12: 219–226, 1980

    Google Scholar 

  59. Houchens DP, Johnson RK, Gaston MR, Goldin A: Toxicity of cancer chemotherapeutic agents in athymic (nude) mice. Cancer Treat Rep 61: 103–104, 1976

    Google Scholar 

  60. Houchens DP, Ovejera AA, Riblet SM, Slagel DE: Human brain tumor xenografts in nude mice as a chemotherapy model. Eur J Cancer Clin Oncol 19: 799–805, 1983

    Google Scholar 

  61. Houghton JA, Taylor DM: Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice. Br J Cancer 37: 199–212, 1978

    Google Scholar 

  62. Houghton JA, Taylor DM: Growth characteristics of human colorectal tumours during serial passage in immunedeprived mice. Br J Cancer 37: 213–223, 1978

    Google Scholar 

  63. Inaba M, Tashiro T, Kobayashi T, Fujimoto S, Sakurai Y, Maruo K, Ohnishi Y, Ueyama Y, Nomura T: Evaluation of response rates to various antitumor agents of human gastric tumors implanted in nude mice. Jpn J Cancer Res (Gann) 77: 190–196, 1986

    Google Scholar 

  64. Inoue K, Fujimoto S, Ogawa M: Antitumor efficacy of seventeen anticancer drugs in human breast cancer xenograft (MX-1) transplanted in nude mice. Cancer Chemother Pharmacol 10: 182–186, 1983

    Google Scholar 

  65. Kawamura E, Miyagawa T, Kurokawa T, Toyoda H, Suzuki T, Kawakubo Y, Takayama K, Miura Y: The improvement of transplantability of cancer from human digestive organs in nude mice and its application to the study of chemotherapy and immunotherapy. J Jap Cancer Ther 13: 689–699, 1978

    Google Scholar 

  66. Kleine L: Growth of malignant gynecological tumors xenotransplanted into thymusaplastic nu/nu mice. Gynec Oncol 24: 286–298, 1986

    Google Scholar 

  67. Kopper L, Steel GG: The therapeutic response of three human tumor lines maintained in immune-suppressed mice. Cancer Res 35: 2704–2713, 1975

    Google Scholar 

  68. Kopper L, Lapis K, Hegedüs C: Chemotherapeutic sensitivity of human colorectal tumor xenografts. Oncology 37, Suppl 1: 42–50, 1980

    Google Scholar 

  69. Kubota T, Shimosato Y, Nagai K: Experimental chemotherapy of carcinoma of the human stomach and colon serially transplanted in nude mice. Gann 69: 299–309, 1978

    Google Scholar 

  70. Kubota T, Nakada M, Tsuyuki K, Inada T, Asanuma F, Ishibiki K, Abe O: Cell kinetics and chemosensitivity of human carcinomas serially transplanted into nude mice. Jpn J Cancer Res (Gann) 77: 502–507, 1986

    Google Scholar 

  71. Kubota T, Hanatani Y, Tsuyuki K, Nakada M, Asanuma F, Okazaki M, Ishibiki K, Abe O, Nakajima E, Maruyama K: Antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea (ACNU) on human colon carcinomas transplanted into nude mice. Jpn J Clin Oncol 12: 33–42, 1982

    Google Scholar 

  72. Kullander S, Rausing A, Trope C: Human ovarian tumours heterotransplanted to ‘nude’ mice. Acta Obstet Gynecol Scand 57: 149–159, 1978

    Google Scholar 

  73. Kyriazis AA, Kyriazis AP: Preferential sites of growth of human tumors in nude mice following subcutaneous transplantation. Cancer Res 40: 4509–4511, 1980

    Google Scholar 

  74. Kyriazis AP, Dipersio L, Michael JG, Pesce AJ: Influence of the mouse hepatitis virus (MHV) infection on the growth of human tumors in the athymic mouse. Int J Cancer 23: 402–409, 1979

    Google Scholar 

  75. Martinotti MG, Arione R, Foa R, Pegoraro L, Jemma C, Forni G: Serial transplantation of a human acute T lymphoblastic leukemia into nude mice. Tumori 72: 553–558, 1986

    Google Scholar 

  76. Maruo K, Ueyama Y, Hioki K, Saito M, Nomura T, Tamaoki N: Strain-dependent growth of a human carcinoma in nude mice with different genetic backgrounds. Expl Cell Biol 50: 115–119, 1982

    Google Scholar 

  77. Maruyama Y, Feola JM, Van Nagell JR: Heterotransplantation of human cervix cancers in radiation-conditioned or nonconditioned athymic mice. Cancer 56: 2635–2639, 1985

    Google Scholar 

  78. Mattern J, Wayss K, Volm M: Effect of five antineoplastic agents on tumor xenografts with different growth rates. J Natl Cancer Inst 72: 1335–1339, 1984

    Google Scholar 

  79. Mattern J, Wayss K, Volm M: Optimum time sequence for the administration of cyclophosphamide and other drugs in vivo. Anticancer Res 5: 173–178, 1985

    Google Scholar 

  80. Mattern J, Haag D, Wayss K, Volm M: Growth kinetics of human lugn tumours in nude mice. Exp Cell Biol 49: 34–40, 1981

    Google Scholar 

  81. Mattern J, Haag D, Wayss K, Volm M: Significance of proliferation for the growth of xenografted human tumours in nude mice. Anticancer Res: 1: 15–18, 1981

    Google Scholar 

  82. Mattern J, Jäger S, Sonka J, Wayss K, Volm M: Growth of human bronchial carcinomas in nude mice. Br J Cancer 51: 195–200, 1985

    Google Scholar 

  83. Mattern J, Wayss K, Haag D, Toomes H, Volm M: Different growth rates of lung tumours in man and their xenografts in nude mice. Eur J Cancer 16: 289–291, 1980

    Google Scholar 

  84. Member B, Helson L, Helson C, Erlandson R, Hajdu S: Human meningeal sarcoma heterotransplants in nu/nu mice treated with L-phenylalanine mustard (L-PAM) and dianhydrogalactitol (DAG). Anticancer Res 5: 559–564, 1985

    Google Scholar 

  85. Naito S, von Eschenbach AC, Fidler IJ: Different growth pattern and biologic behavior of human renal cell carcinoma implanted into different organs of nude mice. J Natl Cancer Inst 78: 377–385, 1987

    Google Scholar 

  86. Nakatani K, Miyagi N, Ezaki T, Shiratori T: Heterotrans-plantation of human stomach carcinomas into nude mice. Effect of MMC and 5-FU on 7 strains of transplantable human gastric cancer in nude mice. J Jpn Soc Cancer Ther 17: 1023–1028, 1982

    Google Scholar 

  87. Nauta MM, Boven E, Schluper HMM, Erkelens CAM, Pinedo HM: Enhanced transplantability of human ovarian cancer lines in cyclophosphamide-pretreated nude mice. Br J Cancer 54: 331–335, 1986

    Google Scholar 

  88. Noruma T, Ohsawa N, Tamaoki N, Fujiwara K: List of human tumors transplanted to nude mice. In: Nomura T, Ohsawa N, Tamaoki N, Fujiwara K (eds) Proceedings of the Second International Workshop on Nude Mice. Stuttgart: G. Fischer-Verlag, 1977, pp 587–595

    Google Scholar 

  89. Nowak K, Peckman MJ, Steel GG: Variation in response of xenografts of colorectal carcinoma to chemotherapy. Br J Cancer 37: 576–584, 1978

    Google Scholar 

  90. Osieka R: Human malignant melanoma: preclinical and clinical drug evaluation. Behring Inst Mitt 74: 353–367, 1984

    Google Scholar 

  91. Pantelouris EM: Absence of thymus in a mouse mutant. Nature 217: 370–371, 1968

    Google Scholar 

  92. Patterson WB, Chute RN, Sommer SC: Transplantation of human tumor into cortisone-treated hamsters. Cancer Res 14: 656–659, 1954

    Google Scholar 

  93. Pettengill OS, Curphey TJ, Cate CC, Flint CF, Maurer LH, Sorenson GD: Animal model for small cell carcinoma of the lung: effect of immunosuppression and sex of mouse on tumor growth in nude athymic mice. Exp Cell Biol 48: 279–297, 1980

    Google Scholar 

  94. Pickard RG, Cobb LM, Steel GG: The growth kinetics of xenografts of human colorectal tumours in immune deprived mice. Br J Cancer 31: 36–45, 1975

    Google Scholar 

  95. Povlsen CO, Jabobsen GK: Chemotherapy of a human malignant melanoma transplanted in the nude mouse. Cancer Res 35: 2790–2796, 1975

    Google Scholar 

  96. Povlsen CO, Rygaard J: Heterotransplantation of human adenocarcinomas of the colon and rectum to the mouse mutant nude. A study of nine consecutive transplantations. Acta Pathol Microbiol Scand Sect A 79: 159–169, 1971

    Google Scholar 

  97. Pratesi G, Pezzoni G, Giardini R, Doci R, Valente M, Parmiani G: Growth characteristics of human colorectal and non-small cell lung tumors xenografted into nude mice: possible correlation with prognosis. Tumori 72: 351–356, 1986

    Google Scholar 

  98. Rae-Venter B, Reid LM: Growth of human breast carcinomas in nude mice and subsequent establishment in tissue culture. Cancer Res 40: 95–100, 1980

    Google Scholar 

  99. Reid LCM, Shin S: Transplantation of heterologous endocrine tumor cells in nude mice. In: Fogh J, Giovanella BC (eds) The Nude Mouse in Experimental and Clinical Research. New York: Academic Press, 1978, pp 313–351

    Google Scholar 

  100. Reid LM, Holland J, Jones C, Wolf B, Niwayama G, William R, Kaplan NO, Sato G: Some of the variables affecting the success of transplantation of human tumors into the athymic nude mice. In: Houchens DP, Ovejera AA (eds) Proceedings of the Symposium on the Use of Athymic (nude) Mice in Cancer Research. Stuttgart: G. Fischer-Verlag, 1978, pp 107–121

    Google Scholar 

  101. Rofstad EK, Fodstad O, Lindmo T: Growth characteristics of human melanoma xenografts. Cell Tissue Kinet 15: 545–554, 1982

    Google Scholar 

  102. Sawada M, Matsui Y, Okudaira Y: Establishment of a new ovarian tumor line in nude mice and its application to treatment of the donor patient. Gynec Oncol 21: 320–330, 1985

    Google Scholar 

  103. Schabel FM, Griswold DP, Laster WR, Corbett TH, Lloyd HH: Quantitative evaluation of anticancer agent activity in experimental animals. Pharmac Ther A 1: 411–435, 1977

    Google Scholar 

  104. Schold SC, Bigner DD: Treatment of five subcutaneous human glioma tumor lines in athymic mice with carmustine, procarbazine, and mithramycin. Cancer Treat Rep 67: 811–819, 1983

    Google Scholar 

  105. Schold SC, Bullard DE, Bigner SH, Jones TR, Bigner DD: Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice. J Neuro-Oncol 1: 5–14, 1983

    Google Scholar 

  106. Sebesteny A, Taylor-Papadimitriou J, Ceriani R, Millis R, Schmitt C, Trevan D: Primary human breast carcinomas transplantable in the nude mouse. J Natl Cancer Inst 63: 1331–1337, 1979

    Google Scholar 

  107. Shapiro WR, Basler GA, Chernik NL, Posner JB: Human brain tumor transplantation into nude mice. J Natl Cancer Inst 62: 447–453, 1979

    Google Scholar 

  108. Sharkey FE, Bains-Grebner M: Increased mitotic activity in human tumors transplanted to athymic nude mice. In: Reed ND (ed) Proceedings of the Third International Workshop on Nude Mice. New York, G. Fischer, 1982, pp 457–462

    Google Scholar 

  109. Sharkey FE, Fogh J: Metastasis of human tumors in athymic nude mice. Int J Cancer 24: 733–738, 1979

    Google Scholar 

  110. Sharkey FE, Fogh J: Considerations in the use of nude mice for cancer research. Cancer Met Rev 3: 341–360, 1984

    Google Scholar 

  111. Sharkey FE, Spicer JH, Fogh J: Changes in histological differentiation of human tumors transplanted to athymic nude mice: a morphometric study. Expl Cell Biol 53: 100–106, 1985

    Google Scholar 

  112. Sharkey FE, Fogh JM, Hajdu SI, Fitzgerald PJ, Fogh J: Experience in surgical pathology with human tumor growth in the nude mouse. In: Fogh J, Giovanella BC (eds) The Nude Mouse in Experimental and Clinical Research. New York: Academic Press, 1978, pp 187–214

    Google Scholar 

  113. Shimosato Y, Kameya T, Nagai K, Hirohashi S, Koide T, Hayashi H, Nomura T: Transplantation of human tumors in nude mice. J Natl Cancer Inst 56: 1251–1260, 1976

    Google Scholar 

  114. Shorthouse AJ, Carter SM, Ellison ML: Tumour marker production in human bronchial carcinoma xenografts. Oncodevelopmental Biology and Medicine 3: 273–281, 1982

    Google Scholar 

  115. Shorthouse AJ, Peckham MJ, Smyth JF, Steel GG: The therapeutic response of bronchial carcinoma xenografts: a direct patient-xenograft comparison. Br J Cancer 41 Suppl IV: 142–145, 1980

    Google Scholar 

  116. Shorthouse AJ, Jones JM, Steel GG, Peckham MJ: Experimental combination and single-agent chemotherapy in human lung tumor xenografts. Br J Cancer 46: 35–44, 1980

    Google Scholar 

  117. Shorthouse AJ, Smyth JF, Steel GG, Ellison M, Mills J, Peckham MJ: The human tumour xenograft — a valid model in experimental chemotherapy? Br J Surg 67: 715–722, 1980

    Google Scholar 

  118. Slagel DE, Feola J, Houchens DP, Ovejera AA: Combined modality treatment using radiation and/or chemotherapy in an athymic nude mouse-human medullablastoma and glioblastoma xenograft model. Cancer Res 42: 812–816, 1982

    Google Scholar 

  119. Sordat B, Fritsche R, Mach JP, Carrel S, Ozzello L, Cerottini JC: Morphological and functional evaluation of human solid tumours serially transplanted in nude mice. In: Rygaard J, Povlsen CD (eds) Proceedings of the First International Workshop on Nude Mice. Stuttgart: G. Fischer-Verlag, 1974, pp 269–277

    Google Scholar 

  120. Southam CM, Tanzi AF, Ross SL: Growth of primary explants of human cancer in newborn rats. Cancer 19: 1670–1682, 1966

    Google Scholar 

  121. Sparrow S, Jones M, Billington S, Stace B: The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts. Br J Cancer 53: 793–797, 1986

    Google Scholar 

  122. Steel GG (ed): Growth Kinetics of Tumors. Oxford: Clarendon Press, 1971

    Google Scholar 

  123. Steel GG: The growth and therapeutic response of human tumours in immune deficient mice. Bull Cancer 65: 465–472, 1978

    Google Scholar 

  124. Steel GG, Courtenay VD, Peckham MJ: The response to chemotherapy of a variety of human tumour xenografts. Br J Cancer 47: 1–13, 1983

    Google Scholar 

  125. Steel GG, Courtenay VD, Rostom AY: Improved immunesuppression techniques for the xenografting of human tumours. Br J Cancer 37: 224–230, 1978

    Google Scholar 

  126. Torhorst J: Wachstumsstimulation eines Ewing-Sarkoms nach ‘Makrophagen-Blockade’ in thymuslosen (nude) Mäusen. Schweiz med Wschr 111: 1319–1321, 1981

    Google Scholar 

  127. Visfeldt J, Povlsen CO, Rygaard J: Chromosome analyses of human tumours following heterotransplantation to the mouse mutant nude. Acta Path Microbiol Scand Section A 80: 169–176, 1972

    Google Scholar 

  128. Von Eyben FE, Trope C, Ljungberg O, Alm P, Wennerberg J, Gulberg B: Histologic pattern and growth in two human testis cancers before and after transplantation to nude mice. Cancer 50: 2845–2853, 1982

    Google Scholar 

  129. Walker MJ, Chaudhuri PK, Dasgupta TK, Beattie CW: Influence of host sex on the growth of human melanoma (40940). Proc Sec Exp Biol Med 165: 96–99, 1980

    Google Scholar 

  130. Warenius HM: Identification and separation of mouse and human components of heterotransplanted tumours. In: Sparrow S (ed) Immuno-deficient Animals for Cancer Research. London: MacMillan, 1980, pp 207–220

    Google Scholar 

  131. Wassermann TH, Comis RL, Goldsmith M, Handelsman H, Penta JS, Slavik M, Soper WT, Carter SK: Tabular analysis of the clinical chemotherapy of solid tumors. Cancer Chemother Rep Part 3, 6: 399–419, 1975

    Google Scholar 

  132. Wist E, Millar JL, Shorthouse AJ: Melphalan uptake in relation to vascular and extracellular space of human lung tumour xenografts. Br J Cancer 43: 458–463, 1981

    Google Scholar 

  133. Wynn-Williams A, McCulloch P: Human cancer and other transplants in the ‘nude’ mouse. J Pathol 122: 225–228, 1977

    Google Scholar 

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Authors and Affiliations

  1. Department of Experimental Pathology, German Cancer Research Center, Im Neuenheimer Feld 280, 6900, Heidelberg, FRG

    Jürgen Mattern, Mihaly Bak, Eric W. Hahn & Manfred Volm

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  1. Jürgen Mattern
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  2. Mihaly Bak
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  3. Eric W. Hahn
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  4. Manfred Volm
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Mattern, J., Bak, M., Hahn, E.W. et al. Human tumor xenografts as model for drug testing. Cancer Metast Rev 7, 263–284 (1988). https://doi.org/10.1007/BF00047755

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