Abstract
In June of 1908, Paul Ehrlich, the founder of immunology, lectured at the University of Amsterdam on the subject of cancer. His remarks included the following: “the understanding of natural immunity really represents the key to carcinoma…. I have acquired the firm conviction that natural immunity does not depend on the presence of anti-microbial materials, but rather, it depends on purely cellular activities. I am certain that, in the enormously complicated course of fetal and post-fetal development, aberrant cells become unusually common. Fortunately, in the majority of people, they remain completely latent thanks to the organism’s positive mechanisms. If such mechanisms did not exist, one might expect carcinomas to have an enormous frequency. These cells may live in a latent state for 20, 30 or 40 years before changing to a significant tumor. This means, in light of my theory, that there has been a diminution of some vital cell activity [which] allows the rapid, parasitic growth of certain cells” (Ehrlich, 1957).
The essential feature of a strategy of discovery lies in determining the sequence of choice of problems to solve. Now it is in fact very much more difficult to see a problem than to find a solution for it. The former requires imagination, the latter only ingenuity. —J. D. Bernal
Dr. Melief is the recipient of a fellowship from the Dutch Organization for the Advancement of Pure Research (ZWO). Supported by grants from USPHS (CA 10018) and the Damon Runyon Foundation.
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Melief, C.J.M., Schwartz, R.S. (1975). Immunocompetence and Malignancy. In: Becker, F.F. (eds) Cancer. A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4449-0_5
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