Biology Direct

Call for Papers: Frontiers and Challenges in Structural Biology

Biology Direct welcomes submissions for a new Collection of structural biology articles. The Collection will include contributions with significant impact on understanding the architecture and function of biological macromolecules, advancing biological theory, and fostering biotechnological/medical applications.

Call for Papers: Bioinformatics Theory and Methods for Biological Discovery

Biology Direct is proud to announce a new Collection that aims to demonstrate innovative approaches addressing biological and medical challenges using computational techniques that support new engineering applications, analytic-method development, or mathematical foundations of biological systems.

Featured Editorial: New hope for the World Cancer Day

The Editor-in-Chief and Editorial Board Members of Biology Direct have collaborated on an editorial where they share that "World Cancer Day is not just a day of reflection but also a call to action to accelerate innovation, foster global collaboration, and ensure that every patient can benefit from the promise of personalized medicine."

Authors: Gerry Melino, Julia Bischof, Wen-Lian Chen, Wei Jia, Harmut Juhl, Gelina S Kopeina, Alessandro Mauriello, Flavia Novelli, Manuel Scimeca, Yufang Shi, Brunella Maria Pirozzi, Giuseppe Sica, Alexey V. Zamaraev & Boris Zhivotovsky 

Image: © AddMeshCube / stock.adobe.com

Featured Article: Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight

The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine methylation in two genetic lines of Arabidopsis thaliana, wild-type Col-0 and the mutant elp2-5, which is deficient in an epigenetic regulator Elongator Complex Subunit 2 (ELP2). Whole-genome bisulfite sequencing (WGBS) revealed distinct spaceflight associated methylation differences, presenting the need to explore specific space-altered methylation at single-molecule resolution to associate specific changes over large regions of spaceflight related genes. To date, tools of multiplexed targeted DNA methylation sequencing remain limited for plant genomes.

Mingqi Zhou, Alberto Riva, Marie-Pierre L. Gauthier, Michael P. Kladde, Robert J. Ferl & Anna-Lisa Paul