The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Thursday, August 22nd, 2024
utilization graph
Last 24 hrs
149,701 jobs submitted
120,062 jobs completed
3,170,680 CPU hrs used
26 NIH Institutes
282 Principal Investigators
638 users

Announcements
Recent Papers that used Biowulf & HPC Resources

Retracing the evolution of Pneumocystis species, with a focus on the human pathogen Pneumocystis jirovecii
Cissé, OH; Ma, L; Kovacs, JA; ,
Microbiol Mol Biol Rev , DOI://10.1128/mmbr.00202-22 (2024)


thumbnail image from paper The recovery of parabolic avalanches in spatially subsampled neuronal networks at criticality
Srinivasan, K; Ribeiro, TL; Kells, P; Plenz, D; ,
Sci Rep , DOI://10.1038/s41598-024-70014-4 (2024)


Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium
Yeung, E; Biedrzycki, RJ; Gómez Herrera, LC et al.
Aging Cell , DOI://10.1111/acel.14194 (2024)


thumbnail image from paper ModDotPlot-rapid and interactive visualization of tandem repeats
Sweeten, AP; Schatz, MC; Phillippy, AM; ,
Bioinformatics , DOI://10.1093/bioinformatics/btae493 (2024)


Comparative Evaluation of LLMs in Clinical Oncology
Rydzewski, NR; Dinakaran, D; Zhao, SG et al.
NEJM AI , DOI://10.1056/aioa2300151 (2024)


thumbnail image from paper TGF-β neutralization attenuates tumor residency of activated T cells to enhance systemic immunity in mice
Fay, M; Sievers, C; Robbins, Y et al.
iScience , DOI://10.1016/j.isci.2024.110520 (2024)


Lack of genetic evidence for NLRP3 inflammasome involvement in Parkinson's disease pathogenesis
Senkevich, K; Liu, L; Alvarado, CX et al.
NPJ Parkinsons Dis , DOI://10.1038/s41531-024-00744-9 (2024)


High-throughput image processing software for the study of nuclear architecture and gene expression
Keikhosravi, A; Almansour, F; Bohrer, CH et al.
Sci Rep , DOI://10.1038/s41598-024-66600-1 (2024)