BDN 0.13.1.1835 from nightlies is supposed to run NativeAOT with current machines CPU features, yet with a .Net Framework host on an AVX2 machine I got:

// Runtime=.NET 7.0.0-rc.1.22401.2, X64 NativeAOT SSE4.2
// GC=Concurrent Workstation
// HardwareIntrinsics=SSE4.2,AES,LZCNT,PCLMUL,POPCNT VectorSize=128

which was due to the fact the host can't check for their support on Net Framework (I don't understand why it's SSE4.2, not SSE2 though, does NativeAOT default to that? if yes then that's a bit weird).
A possible solution would be to generate a separate .Net app that'd perform the CPU checks and return the data to the Net Framework host.