Now that Serenity can run on VirtualBox (with NX enabled), there's several issues that have cropped up while using it:

• While SB16 is detected, there is still no audio.
  serenity.txt VBox.log

• Scrolling up actually scrolls down rapidly. Fixed by Kernel: Scroll wheel amount on Intellimouse is 4 bits instead of 8 #3289.

• E1000 adapter causes an MMIO fault in out16 while trying to set the interrupt rate. Fixed by Kernel/Net: E1000 interrupt rate register is 32-bit, not 16-bit #4489.
  However, if you use Intel PRO/1000 MT Desktop (82540EM), it shares an IRQ with the ACPI parser. This causes a crash because the ACPI parser is not implemented yet.

• Shutting down does nothing but freeze the entire system in the not responding state. Fixed by Kernel: Add shutdown commands for other virtualizers #3351.