Rewriting Ne as a set is an ill-defined process and should be used with care. This is discussed in #22327.

Briefly, Ne(x, 2), without knowledge about x, can be expressed as the set Complement(Universalset, {2}) but it is writtn in master as Union(Interval.open(-oo, 2), Interval.open(2, oo)) which implies that x is real...but it need not be, e.g. Ne(zoo, 2) is True but zoo is not in the reported Union.