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A method to predict activating, deactivating and resistance mutations in kinases

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russelllab/kinaseResistance

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Activark is a predictor of activating, deactivating and resistance mutations in kinases

Access the webserver here


How to run Activark?

Move to the directory (mandatory)

cd ML/

See the help section

./prepareTestData.py -h

Example:

./prepareTestData.py sample_mutations.txt


Performance

10-fold stratified CV for the AD predictor ROC

10-fold stratified CV on shuffled dataset ROC_shuffled


Feature importance

Performance


Best Decision tree

Performance


Database

Activark uses the following DB schema: Database