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MLoutput7all.txt
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MLoutput7all.txt
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all
mean_test_score [0.86990108 0.86990108 0.86987273 0.86977005 0.86959109 0.86959109
0.86959109 0.86959109 0.86913971 0.86913971 0.86913971 0.86913971
0.86812085 0.86812085 0.86812085 0.86812085 0.88716787 0.88716787
0.88703395 0.88658209 0.88568381 0.88568381 0.88568381 0.88568381
0.88446163 0.88446163 0.88446163 0.88446163 0.88271724 0.88271724
0.88271724 0.88271724 0.89549541 0.89549541 0.89517162 0.89483907
0.89346993 0.89346993 0.89346993 0.89346993 0.89242981 0.89242981
0.89242981 0.89242981 0.88870222 0.88870222 0.88870222 0.88870222
0.90482697 0.90482697 0.90447991 0.90419532 0.90282742 0.90282742
0.90282742 0.90282742 0.89999933 0.89999933 0.89999933 0.89999933
0.89539699 0.89539699 0.89539699 0.89539699 0.91034883 0.91034883
0.90997387 0.90978112 0.90700548 0.90700548 0.90700548 0.90700548
0.90247713 0.90247713 0.90247713 0.90247713 0.89754216 0.89754216
0.89754216 0.89754216]
-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-#-
Best model: {'criterion': 'gini', 'max_depth': 10, 'max_features': 'sqrt', 'min_samples_leaf': 3, 'min_samples_split': 3, 'n_estimators': 100}
########################
Feature Importance
12 mammals_0 0.051466
5 allHomologs_0 0.045048
14 vertebrates_0 0.040413
11 eukaryotes_0 0.039721
13 metazoa_0 0.036596
9 bpso_0 0.034551
8 orthologs_0 0.032607
10 bpsh_0 0.032324
0 hmmScoreWT 0.031823
7 specParalogs_0 0.029013
16 D_N_0_pfam 0.021912
15 D_A_0_pfam 0.018602
3 p_0_pfam 0.018314
2 Phosphomimic 0.017962
4 A_MUT 0.016358
6 exclParalogs_0 0.016350
17 D_S_0_pfam 0.015535
1 hmmScoreMUT 0.015242
########################
activatingresistance results ( 14 )
P21802/FGFR2/E565A 1 [0.08779999 0.46788397 0.44431603]
P21802/FGFR2/K641R 2 [0.31346748 0.31204072 0.3744918 ]
P21802/FGFR2/N549H 2 [0.23555971 0.11566833 0.64877196]
P21802/FGFR2/N549T 2 [0.1574034 0.16541374 0.67718286]
Q9UM73/ALK/F1174L 0 [0.47544247 0.14706685 0.37749067]
Q9UM73/ALK/F1174V 2 [0.28490921 0.17791432 0.53717647]
P36888/FLT3/D835H 2 [0.02035391 0.03886535 0.94078074]
P36888/FLT3/D835V 2 [0.02775399 0.02695338 0.94529263]
P36888/FLT3/D835Y 2 [0.01686421 0.02887598 0.9542598 ]
P11362/FGFR1/N546K 2 [0.24618229 0.12454262 0.62927509]
P15056/BRAF/V600E 2 [0.04195894 0.10753103 0.85051003]
P10721/KIT/D816H 2 [0.03656154 0.0462407 0.91719776]
P10721/KIT/N822K 2 [0.1876069 0.25761159 0.55478151]
P16234/PDGFRA/D842V 2 [0.03227555 0.03071994 0.93700451]
REC: 0.8571428571428571
########################
P00533/EGFR/T790M [0.40854086 0.22307359 0.36838555] 0 increaseresistance
########################
########################
P46734/MAP2K3/A84T [0.79648126 0.05248211 0.15103663] 0 A
P11309/PIM1/S97N [0.64210909 0.17758103 0.18030988] 0 A
########################
Q00535/CDK5/F82I [0.17369089 0.41111932 0.4151898 ] 2 TBD
Q02750/MAP2K1/V211D [0.11697907 0.47251833 0.4105026 ] 1 TBD
########################
O96017/CHEK2/K373E [0.18227886 0.24997346 0.56774769] 2 Inconclusive
P06493/CDK1/V124G [0.1292152 0.59277396 0.27801084] 1 Inconclusive
P46734/MAP2K3/R94L [0.23428393 0.29813949 0.46757659] 2 Inconclusive
P46734/MAP2K3/R96W [0.28076151 0.40850839 0.31073009] 1 Inconclusive
P46734/MAP2K3/L215W [0.2146659 0.43789505 0.34743905] 1 Inconclusive
P46734/MAP2K3/T222M [0.07200279 0.64302016 0.28497705] 1 Inconclusive
P11309/PIM1/Q127E [0.47545814 0.18911707 0.33542479] 0 Inconclusive
Q06418/TYRO3/V669L [0.4013141 0.29279955 0.30588635] 0 Inconclusive
Q13470/TNK1/A299D [0.53363436 0.12116929 0.34519635] 0 Inconclusive
########################
########################
########################
P00533/EGFR/L858R [0.12205353 0.36608753 0.51185894] 2 activating
REC: activating 0.927
########################
REC: increase 0.865
########################
REC: neutral 0.939
########################
REC: loss 0.965
########################
REC: decrease 0.747