Skip to content

Incorrect germline assignment #69

Open
@dg1002

Description

With an antibody sequence I have, I get different germline assignments from ANARCI and IgBLAST.
IgBLAST assigned germline IGKV7-301 for my sequence while ANARCI gave IGKV3-1101.
At first, I guessed that it's something about the HMM algorithm that makes the result different.
However, if I run IGKV7-301 germline sequence through ANARCI, it's assigned to be IGKV3-1101.

Does anyone have a good idea why this is so?
Thanks in advance.

FYI, IGKV7-3*01 amino acid sequence is

IGKV7-3*01
DIVLTQSPASLAVSPGQRATITCRASESVSFLGINLIHWYQQKPGQPPKLLIYQASNKDTGVPARFSGSGSGTDFTLTINPVEANDTANYYCLQSKNFP
according to the IMGT database.

Metadata

Assignees

No one assigned

    Labels

    No labels
    No labels

    Type

    No type

    Projects

    No projects

    Milestone

    No milestone

    Relationships

    None yet

    Development

    No branches or pull requests

    Issue actions